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Neurodegenerative diseases (view source)
Revision as of 01:03, 30 August 2011
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==Prion diseases== | ==Prion diseases== | ||
===General=== | |||
Etiology:<ref name=pmid16609731>{{cite journal |author=Watts JC, Balachandran A, Westaway D |title=The expanding universe of prion diseases |journal=PLoS Pathog. |volume=2 |issue=3 |pages=e26 |year=2006 |month=March |pmid=16609731 |pmc=1434791 |doi=10.1371/journal.ppat.0020026 |url=}}</ref> | Etiology:<ref name=pmid16609731>{{cite journal |author=Watts JC, Balachandran A, Westaway D |title=The expanding universe of prion diseases |journal=PLoS Pathog. |volume=2 |issue=3 |pages=e26 |year=2006 |month=March |pmid=16609731 |pmc=1434791 |doi=10.1371/journal.ppat.0020026 |url=}}</ref> | ||
*Misfolded cell-surface protein called PrP | *Misfolded cell-surface protein called PrP<sup>SC</sup>. | ||
**This is derived from the protein ''PrP<sup>C</sup>'' encoded by the ''PRNP'' gene. | |||
Includes: | Includes: | ||
*Creutzfeldt-Jakob disease (CJD). | *Creutzfeldt-Jakob disease (CJD). | ||
*Sporadic fatal insomnia (sFI). | *Sporadic fatal insomnia (sFI).<ref name=pmid16609731>{{cite journal |author=Watts JC, Balachandran A, Westaway D |title=The expanding universe of prion diseases |journal=PLoS Pathog. |volume=2 |issue=3 |pages=e26 |year=2006 |month=March |pmid=16609731 |pmc=1434791 |doi=10.1371/journal.ppat.0020026 |url=}}</ref> | ||
*Fatal familial insomnia (FFI).<ref name=Ref_PCPBoD8_672>{{Ref PCPBoD8|672}}</ref> | |||
*Gestmann-Straussler-Scheinker syndrome (GSS) - due to PRNP gene mutations.<ref name=Ref_PCPBoD8_671>{{Ref PCPBoD8|671}}</ref> | |||
===IHC=== | |||
PrP<sup>C</sup>:<ref name=Ref_PCPBoD8_672>{{Ref PCPBoD8|672}}</ref> | |||
*Congo red +ve. | |||
*PAS +ve. | |||
==Creutzfeldt-Jakob disease== | ==Creutzfeldt-Jakob disease== | ||