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Difference between revisions of "Uterine cervix"
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→Histologic changes in CIN I, CIN II and CIN III
(→Tunnel cluster: format) |
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*CIN I = cytoplasmic halos (koilocytic atypia), atypical cells close to basement membrane only. | *CIN I = cytoplasmic halos (koilocytic atypia), atypical cells close to basement membrane only. | ||
**Nuclear enlargement -- >=3:1 enlarged nucleus:normal nucleus. | **Nuclear enlargement -- >=3:1 enlarged nucleus:normal nucleus. | ||
**Binucleation may be seen (cytopathic effect of HPV).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref> | **Binucleation may be seen (cytopathic effect of [[HPV]]).<ref name=pmid11491378>{{cite journal |author=Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ |title=Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible |journal=Clin Exp Obstet Gynecol |volume=28 |issue=2 |pages=78–80 |year=2001 |pmid=11491378 |doi= |url=}}</ref> | ||
*CIN II = increased nuclear-cytoplasmic ratio, loss of polarity, incr. mitoses, hyperchromasia. | *CIN II = increased nuclear-cytoplasmic ratio, loss of polarity, incr. mitoses, hyperchromasia. | ||
**If there are large nuclei... you should seen 'em on low power, i.e. 25x. | **If there are large nuclei... you should seen 'em on low power, i.e. 25x. | ||