Talk:Uterine cervix

LSIL criteria

The London (cytology) criteria - 2 of 3:

1. Perinuclear clearing.
2. Membrane irregularities (5 cells in one field - FD ~ 1.1 mm).
3. Nuclear enlargement > 2x lymphocyte.

Augmented (London) criterium includes:

• Neoplastic transisition (sharp transisition from normal to abnormal - gradient over 2-3 cell distance).

Required if #3 not obvious:

• Binucleation (>2 cells).

Relative exclusions:

• Nucleoli ( >5 in one field - FD ~ 1.1 mm).

Exclusions:

• Cytoplasm to nucleus ratio =< 2:1; HSIL or invasive SCC.

Cannot exclude HSIL

UTERINE ENDOCERVIX, CURETTAGE:
- VERY SMALL FRAGMENTS WITH AT LEAST LOW-GRADE SQUAMOUS INTRAEPITHELIAL
  LESION (LSIL), SEE COMMENT.
- STRIPPED ENDOCERVICAL EPITHELIUM WITHOUT APPARENT PATHOLOGY.

COMMENT:
The morphology is more in keeping with LSIL; however, a p16 stain shows strong diffuse
staining, as may be seen in the basal cells of a LSIL or a high-grade squamous
intraepithelial lesion (HSIL). HSIL cannot be excluded.

Secretory phase endometrial epithelium vs endocervical epithelium

Endocx:

• Narrower columnar cells/taller.
• Nuclei more cigar like.
• Paler cytoplasm.

Endometrium:

• Wider cells.
• Nuclei rounder.
• Link pink cytoplasm.