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Difference between revisions of "Talk:Breast pathology"
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→Phyllodes: new section
m (→Fibroadenoma) |
(→Phyllodes: new section) |
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Fibrocystic changes.<br> | Fibrocystic changes.<br> | ||
Columnar cell change.<br> | Columnar cell change.<br> | ||
== Phyllodes == | |||
===Microscopic=== | |||
The specimen consists of a close excision lumpectomy. | |||
The sections show a moderately well-circumscribed fibroepithelial lesion, that focally has an irregular interface to the surround breast tissue. It has long slit-like spaces that together give the a leaf-like appearance. The stromal component is mitotically active (10 mitoses / 2.376 mm^2 ) and has moderate nuclear atypia. There is no stromal overgrowth. The epithelial component of the lesion has no nuclear atypia and is not mitotically active. The surgical margin is 0.1 cm from the lesion. | |||
The surrounding breast parenchyma has a small focus of glands without significant mitotic activity, an increased epithelial component -- with more than three cells to the basement membrane, and nuclei that are small and round to oval. There is also focal cystic glandular dilation and epithelium with a columnar cell morphology and apocrine snouts. Calcifications are found in benign breast glands. | |||
The focally irregular interface between the lesion and surrounding breast tissue, and the mitotic rate is concerning for an aggressive (phyllodes) tumour; however other features that typically accompany a malignant behaviour (stromal overgrowth, marked stromal cell nuclear atypia) are absent. | |||
===Final=== | |||
DIAGNOSIS:<br> | |||
Breast, left, (close excision) lumpectomy:<br> | |||
Phyllodes tumour with:<br> | |||
Marked cellular proliferation, and | |||
Focally irregular interface to surround breast tissue – suggest re-excision of lumpectomy cavity. | |||