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Difference between revisions of "Non-invasive breast carcinoma"
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Non-invasive breast carcinoma (view source)
Revision as of 16:30, 4 August 2011
, 16:30, 4 August 2011→Microscopic
(→Ductal carcinoma in situ: more) |
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
* | *Architectural changes: | ||
** | **Equal spacing of cells - "cookie cutter" look. | ||
**Cells line-up along lumen/glandular spaces - form "Roman briges". | |||
*Cells line-up along lumen/glandular spaces - form "Roman briges". | **Architecture suggestive of DCIS - see ''[[Subtypes of DCIS]]'' | ||
*Nuclear changes: | *Nuclear changes: | ||
**Nuclear enlargement - at least 2-3x size of RBC - '''key feature'''. | **Nuclear enlargement - at least 2-3x size of RBC - '''key feature'''. | ||
| Line 73: | Line 73: | ||
*Apocrine changes of cytoplasm -- nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref> | *Apocrine changes of cytoplasm -- nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref> | ||
====Subtypes==== | ====Subtypes of DCIS==== | ||
Subtypes are based on architecture: | Subtypes are based on architecture: | ||
*Solid. | *Solid. | ||