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Difference between revisions of "Non-invasive breast carcinoma"
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Non-invasive breast carcinoma (view source)
Revision as of 16:26, 4 August 2011
, 16:26, 4 August 2011→Ductal carcinoma in situ: more
(→Ductal carcinoma in situ: more) |
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*Diagnosis based on nuclear abnormalities ''and'' architecture. | *Diagnosis based on nuclear abnormalities ''and'' architecture. | ||
*It is typically picked-up during radiologic screening. | *It is typically picked-up during radiologic screening. | ||
===Microscopic=== | ===Microscopic=== | ||
| Line 87: | Line 72: | ||
Note: | Note: | ||
*Apocrine changes of cytoplasm -- nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref> | *Apocrine changes of cytoplasm -- nuclei should be ~4x RBC for low grade, 5x RBC for high grade.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html http://surgpathcriteria.stanford.edu/breast/dcis/apocrinedcis.html]. Accessed on: 4 August 2011.</ref> | ||
====Subtypes==== | |||
Subtypes are based on architecture: | |||
*Solid. | |||
**No spaces between cells. | |||
*Cribriform. | |||
**Honeycomb-like appearance: circular holes. | |||
**"Cookie cutter" appearance/"punched-out" appearance/"Roman bridges" -- cells surround the circular holes. | |||
*Papillary. | |||
**Papillae with fibrovascular cores. | |||
*Micropapillary. | |||
**Small papillae without fibrovascular cores. | |||
**Have "drum stick" shape. | |||
NOTE: ''comedonecrosis'' - used to be considered a separate subtype -- essentially ''solid'' type DCIS with [[necrosis]]. | |||
====Grading DCIS==== | ====Grading DCIS==== | ||
Graded 1-3 (low-high)<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/ http://surgpathcriteria.stanford.edu/breast/dcis/]</ref> - compare lesional nuclei to one another. | Graded 1-3 (low-high)<ref>URL: [http://surgpathcriteria.stanford.edu/breast/dcis/ http://surgpathcriteria.stanford.edu/breast/dcis/]. Accessed on: 4 August 2011.</ref> - compare lesional nuclei to one another. | ||
*Grade 1: | *Grade 1: | ||
**Nuclei 2-3x size of RBC. | **Nuclei 2-3x size of RBC. | ||
** | **No necrosis. | ||
*Grade 2: | *Grade 2: | ||
**Nuclei 2-3x size of RBC. | **Nuclei 2-3x size of RBC. | ||