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Difference between revisions of "Plasma cell neoplasms"
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m (→General) |
(more clinical) |
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*Malignancy derived from the plasma cells. | *Malignancy derived from the plasma cells. | ||
*Prognosis: poor. | *Prognosis: poor. | ||
* | *Common primary [[bone tumour]] in adults. | ||
Clinical:<ref name=Ref_PCPBoD8_323>{{Ref PCPBoD8|323}}</ref> | Clinical:<ref name=Ref_PCPBoD8_323>{{Ref PCPBoD8|323}}</ref> | ||
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Note: | Note: | ||
*Plasmacytoma = histology of '''multiple myeloma'''; to diagnose ''multiple myeloma'' other (non-pathology) criteria are needed. | *Plasmacytoma = histology of '''multiple myeloma'''; to diagnose ''multiple myeloma'' other (non-pathology) criteria are needed. | ||
===Multiple myeloma=== | |||
Features of multiple myeloma (mnemonic ''CARL''): | |||
*Calcium (in the serum) is elevated. | |||
*[[Anemia]]. | |||
*Renal failure. | |||
*Lytic bone lesions. | |||
''CRAB'' (calclium, renal failure, anemia, bony lesions) is another mnemonic.<ref name=pmid12780789>{{Cite journal | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | month = Jun | year = 2003 | doi = | PMID = 12780789 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features (plasmacytoma): | ||
*Abundant eosinophilic cytoplasm. | *Abundant eosinophilic cytoplasm. | ||
*Eccentrically placed nucleus. | *Eccentrically placed nucleus. | ||