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Difference between revisions of "Small cell carcinoma of the lung"
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Small cell carcinoma of the lung (view source)
Revision as of 22:28, 16 January 2025
, 22:28, 16 January 2025no edit summary
(→Possible LCNEC: tweak) |
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*Other [[small round blue cell tumours]]. | *Other [[small round blue cell tumours]]. | ||
=== | ===Histologic subtypes=== | ||
*Large cell neuroendocrine carcinoma (LCNEC). | *Large cell neuroendocrine carcinoma (LCNEC). | ||
| Line 109: | Line 109: | ||
Others: | Others: | ||
*[[p63]] +ve in ~75-80% of the cases.<ref name=pmid15551738>{{Cite journal | last1 = Au | first1 = NH. | last2 = Gown | first2 = AM. | last3 = Cheang | first3 = M. | last4 = Huntsman | first4 = D. | last5 = Yorida | first5 = E. | last6 = Elliott | first6 = WM. | last7 = Flint | first7 = J. | last8 = English | first8 = J. | last9 = Gilks | first9 = CB. | title = P63 expression in lung carcinoma: a tissue microarray study of 408 cases. | journal = Appl Immunohistochem Mol Morphol | volume = 12 | issue = 3 | pages = 240-7 | month = Sep | year = 2004 | doi = | PMID = 15551738 }}</ref> | *[[p63]] +ve in ~75-80% of the cases.<ref name=pmid15551738>{{Cite journal | last1 = Au | first1 = NH. | last2 = Gown | first2 = AM. | last3 = Cheang | first3 = M. | last4 = Huntsman | first4 = D. | last5 = Yorida | first5 = E. | last6 = Elliott | first6 = WM. | last7 = Flint | first7 = J. | last8 = English | first8 = J. | last9 = Gilks | first9 = CB. | title = P63 expression in lung carcinoma: a tissue microarray study of 408 cases. | journal = Appl Immunohistochem Mol Morphol | volume = 12 | issue = 3 | pages = 240-7 | month = Sep | year = 2004 | doi = | PMID = 15551738 }}</ref> | ||
===Molecular subtypes via IHC=== | |||
==Subtypes== | |||
Based on a cohort of 72 small cell carcinomas:<ref>{{cite journal |authors=Chiang CL, Huang HC, Luo YH, Shen CI, Chao HS, Tseng YH, Chou TY, Schrump DS, Yeh YC, Chen YM |title=Clinical utility of immunohistochemical subtyping in patients with small cell lung cancer |journal=Lung Cancer |volume=188 |issue= |pages=107473 |date=February 2024 |pmid=38232600 |doi=10.1016/j.lungcan.2024.107473 |url=}}</ref> | |||
{| class="wikitable sortable" | |||
!Type | |||
!Prevalence | |||
!Staining with IHC marker | |||
|- | |||
|ASCL1 | |||
| 55% | |||
| 73% | |||
|- | |||
|NEUROD1 | |||
| 27% | |||
| 63% | |||
|- | |||
|POU2F3 | |||
| 10% | |||
| 15% | |||
|- | |||
|YAP1 | |||
| 0% | |||
| 3% | |||
|} | |||
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