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Difference between revisions of "Papillary renal neoplasm with reverse polarity"
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Papillary renal neoplasm with reverse polarity (view source)
Revision as of 19:00, 17 June 2024
, 17 Juneno edit summary
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==Molecular== | ==Molecular== | ||
*[[KRAS]] mutations.<ref name=pmid37797754/> | *[[KRAS]] mutations.<ref name=pmid37797754/> | ||
==Sign out== | |||
<pre> | |||
A. Right Kidney, Tumour, Partial Nephrectomy: | |||
- Papillary renal neoplasm with reverse polarity, see comment. | |||
Comment: | |||
The tumour has a papillary architecture, eosinophilic cytoplasm and reversed nuclear polarity. | |||
It stains as follows: | |||
POSITIVE: CK7 (strong, diffuse), AE1/AE3 (strong, diffuse), GATA3 (moderate, diffuse), AMACR (moderate, diffuse), PAX8 (modreate, diffuse). | |||
NEGATIVE: vimentin (stroma), CD117, CD10. | |||
These tumour are thought to be distinct from papillary RCC.[1][2] Limited data suggests they have an indolent behaviour.[3] | |||
1. Pathol Int. 2024 Apr;74(4):222-226. doi: 10.1111/pin.13417. Epub 2024 Mar 8. | |||
2. Hum Pathol. 2023 Dec:142:1-6. doi: 10.1016/j.humpath.2023.09.011. Epub 2023 Oct 4. | |||
3. Am J Surg Pathol. 2019 Aug;43(8):1099-1111. doi: 10.1097/PAS.0000000000001288. https://pubmed.ncbi.nlm.nih.gov/31135486/ | |||
</pre> | |||
==See also== | ==See also== | ||