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Difference between revisions of "Molecular pathology"
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*Amplification-refractory mutation system (ARMS):<ref name=pmid18428319>{{cite journal |author=Little S |title=Amplification-refractory mutation system (ARMS) analysis of point mutations |journal=Curr Protoc Hum Genet |volume=Chapter 9 |issue= |pages=Unit 9.8 |year=2001 |month=May |pmid=18428319 |doi=10.1002/0471142905.hg0908s07 |url=}}</ref> | *Amplification-refractory mutation system (ARMS):<ref name=pmid18428319>{{cite journal |author=Little S |title=Amplification-refractory mutation system (ARMS) analysis of point mutations |journal=Curr Protoc Hum Genet |volume=Chapter 9 |issue= |pages=Unit 9.8 |year=2001 |month=May |pmid=18428319 |doi=10.1002/0471142905.hg0908s07 |url=}}</ref> | ||
**Technique for finding a (specific) single base change. | **Technique for finding a (specific) single base change. | ||
***The (PCR) primers are designed bind to mutated sequence. | ***The (PCR) primers are designed bind to the mutated sequence. | ||
****If the mutation is present a PCR product is seen. | ****If the mutation is present a PCR product is seen. | ||
****If the mutation is absent no PCR product is seen. | ****If the mutation is absent no PCR product is seen. | ||