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SMARCA4-deficient sinonasal carcinoma (view source)
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'''SMARCA4-deficient sinonasal carcinoma''' is an emerging type of sinonasal carcinoma.<ref name=pmid31934917>{{cite journal |vauthors=Agaimy A, Jain D, Uddin N, Rooper LM, Bishop JA |title=SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies |journal=Am J Surg Pathol |volume=44 |issue=5 |pages=703–710 |date=May 2020 |pmid=31934917 |doi=10.1097/PAS.0000000000001428 |url=}}</ref> | '''SMARCA4-deficient sinonasal carcinoma''' is an emerging type of sinonasal carcinoma.<ref name=pmid31934917>{{cite journal |vauthors=Agaimy A, Jain D, Uddin N, Rooper LM, Bishop JA |title=SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies |journal=Am J Surg Pathol |volume=44 |issue=5 |pages=703–710 |date=May 2020 |pmid=31934917 |doi=10.1097/PAS.0000000000001428 |url=}}</ref> | ||
==Microscopic== | |||
Features: | |||
*Poorly differentiated tumour with large or small cells. | |||
DDx:<ref>{{cite journal |authors=Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D |title=SMARCA4/BRG1-Deficient Sinonasal Carcinoma |journal=Arch Pathol Lab Med |volume=146 |issue=9 |pages=1122–1130 |date=September 2022 |pmid=34871352 |doi=10.5858/arpa.2021-0001-OA |url=}}</ref> | |||
*[[Sinonasal undifferentiated carcinoma]] (SNUC). | |||
*Neuroendocrine carcinoma - [[small cell carcinoma]] and [[large cell neuroendocrine carcinoma]]. | |||
*Teratocarcinosarcoma. | |||
==IHC== | |||
Features:<ref name=pmid31934917/> | |||
*SMARCA4 loss of staining - definitional. | |||
*CK5 -ve. | |||
*p63 -ve. | |||
*p16 -ve. | |||
*NUT -ve. | |||
==See also== | ==See also== | ||
*[[Head and neck pathology]]. | *[[Head and neck pathology]]. | ||
*[[SMARCA4]]. | |||
*[[SMARCB1]] (INI-1). | |||
==References== | ==References== | ||