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Difference between revisions of "Chronic traumatic encephalopathy"
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Chronic traumatic encephalopathy (view source)
Revision as of 12:43, 17 October 2022
, 12:43, 17 October 2022CTE staging
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Jensflorian (talk | contribs) (CTE staging) |
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*Wall-to-wall neurofibrillary tangles. | *Wall-to-wall neurofibrillary tangles. | ||
**Common in olfactory bulb, mammillary bodies, hippocampus. | **Common in olfactory bulb, mammillary bodies, hippocampus. | ||
**Usually perivascular. | **Usually perivascular around small blood vessels. | ||
**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci. | **Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci. | ||
*** But not restricted to superficial regions of sulci (also deep in parenchyma). | |||
**Staging according to Bienik et al.: NFT in <5 regions: low CTE, in 5 or more: high CTE.<ref>{{cite journal |vauthors=Snijders RJ, De Courcy-Wheeler RH, Nicolaides KH |title=Intrauterine growth retardation and fetal transverse cerebellar diameter |journal=Prenat Diagn |volume=14 |issue=12 |pages=1101–5 |date=December 1994 |pmid=7899277 |doi=10.1002/pd.1970141202 |url=}}</ref> | |||
==IHC== | ==IHC== | ||
*Increased TDP-43 staining. | *Increased TDP-43 staining. | ||
*p-Tau neuronal aggregates. | |||
**+/. thron shaped-astrocytes. | |||
*Usu. absence of beta-amyloid. | |||
Note: | Note: | ||