Chronic traumatic encephalopathy

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Chronic traumatic encephalopathy, abbreviated CTE, is a neurodegenerative disease due to repeated trauma.

The in the context of boxing it is known as dementia pugilistica; pugil is boxer in Latin.[1]

General

  • Due to head trauma - usually repetitive.
    • Seen in American football and boxing.
  • May be associated with motor neuron disease.[2]

Microscopic

Features:[3]

  • Wall-to-wall neurofibrillary tangles.
    • Common in olfactory bulb, mammillary bodies, hippocampus.
    • Usually perivascular.
    • Often superficial (unlike Alzheimer disease) and at the deep aspect of sulci.

IHC

  • Increased TDP-43 staining.

Note:

  • ALS associated with traumatic brain injuries.[4]

See also

References

  1. URL: http://dictionary.reference.com/browse/pugilism. Accessed on: 21 November 2011.
  2. Daneshvar, DH.; Riley, DO.; Nowinski, CJ.; McKee, AC.; Stern, RA.; Cantu, RC. (Nov 2011). "Long-term consequences: effects on normal development profile after concussion.". Phys Med Rehabil Clin N Am 22 (4): 683-700. doi:10.1016/j.pmr.2011.08.009. PMID 22050943.
  3. Stern, RA.; Riley, DO.; Daneshvar, DH.; Nowinski, CJ.; Cantu, RC.; McKee, AC. (Oct 2011). "Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy.". PM R 3 (10 Suppl 2): S460-7. doi:10.1016/j.pmrj.2011.08.008. PMID 22035690.
  4. Costanza, A.; Weber, K.; Gandy, S.; Bouras, C.; Hof, PR.; Giannakopoulos, P.; Canuto, A. (Oct 2011). "Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates.". Neuropathol Appl Neurobiol 37 (6): 570-84. doi:10.1111/j.1365-2990.2011.01186.x. PMID 21696410.