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Difference between revisions of "Pituitary gland"
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→Pituitary adenoma: Starting Update on 2022 WHO classification
Jensflorian (talk | contribs) (→gangliocytoma: update according WHO2017) |
Jensflorian (talk | contribs) (→Pituitary adenoma: Starting Update on 2022 WHO classification) |
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=Specific entities= | =Specific entities= | ||
==Pituitary | ==Pituitary neuroendocrine tumor (PitNET)== | ||
Old terminology '''Pituitary adenoma''' is depreceated | |||
===General=== | ===General=== | ||
*Clinical:<ref>{{Ref PBoD8|1100}}</ref> | *Clinical:<ref>{{Ref PBoD8|1100}}</ref> | ||
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**Tumor of adults. | **Tumor of adults. | ||
Classification: | Morphologic Classification: | ||
#Microadenoma <= 1 cm. | #Microadenoma <= 1 cm. | ||
#Macroadenoma 1-4 cm. | #Macroadenoma 1-4 cm. | ||
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*Smears very well.<ref>MUN. 24 November 2010.</ref> | *Smears very well.<ref>MUN. 24 November 2010.</ref> | ||
The WHO | The WHO 2022 Classification of tumours of endocrine organs recoginizes following tumours:<ref>{{cite journal |vauthors=Asa SL, Mete O, Perry A, Osamura RY |title=Overview of the 2022 WHO Classification of Pituitary Tumors |journal=Endocr Pathol |volume=33 |issue=1 |pages=6–26 |date=March 2022 |pmid=35291028 |doi=10.1007/s12022-022-09703-7 |url=}}</ref> | ||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | {| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | ||
! | ! PitNET lineage | ||
! PitNET type | |||
! subtypes | ! subtypes | ||
! Hormone secretion | ! Hormone secretion | ||
! Transcription factor | ! Transcription factor | ||
|- | |- | ||
| | |||
| Somatotroph adenoma | | Somatotroph adenoma | ||
| Densely and sparsely granulated adenoma, Mammosomatotroph adenoma, Mixed GH and PRL adenoma | | Densely and sparsely granulated adenoma, Mammosomatotroph adenoma, Mixed GH and PRL adenoma | ||
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| PIT1 | | PIT1 | ||
|- | |- | ||
| | |||
| Lactotroph adenoma | | Lactotroph adenoma | ||
| Densely and sparsely granulated adenoma, Acidophilic stem cell adenoma | | Densely and sparsely granulated adenoma, Acidophilic stem cell adenoma | ||
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| PIT1, [[Estrogen receptor|ER]] | | PIT1, [[Estrogen receptor|ER]] | ||
|- | |- | ||
| | |||
| Thyrotroph adenoma | | Thyrotroph adenoma | ||
| | | | ||
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| PIT1, [[Estrogen receptor|ER]] | | PIT1, [[Estrogen receptor|ER]] | ||
|- | |- | ||
| | |||
| Corticotroph adenoma | | Corticotroph adenoma | ||
| Densely and sparsely granulated adenoma, Crooke cell adenoma | | Densely and sparsely granulated adenoma, Crooke cell adenoma | ||
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| TPIT | | TPIT | ||
|- | |- | ||
| | |||
| Gonadotroph adenoma | | Gonadotroph adenoma | ||
| Sparsely granulated adenoma | | Sparsely granulated adenoma | ||
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| SF1, [[Estrogen receptor|ER]], GATA2 | | SF1, [[Estrogen receptor|ER]], GATA2 | ||
|- | |- | ||
| | |||
| Null cell adenoma | | Null cell adenoma | ||
| | | | ||