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→Common: astrocytoma grading
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=Common= | |||
==Pilocytic astrocytoma== | |||
* Benign, cystic, infratentorial. | |||
* Classic childhood tumor, surgically resectable. | |||
* Variant: [[Pilomyxoid astrocytoma]] | |||
{{Main|Pilocytic astrocytoma}} | |||
=Common= | =Common= | ||
==Pilocytic astrocytoma== | ==Pilocytic astrocytoma== | ||
| Line 57: | Line 63: | ||
{{Main|Pilocytic astrocytoma}} | {{Main|Pilocytic astrocytoma}} | ||
== | ==Astrocytoma, IDH mutant== | ||
* Grade II | * Astrocytoma, IDH mutant are less common than glioblastoma. | ||
* Usually | * Grade 2-4 depends on histological and molecular criteria: | ||
=== Astrocytoma, IDH mutant grade 2=== | |||
* Formerly designated as Diffuse astrocytoma Grade II. | |||
* Typically seen in adults. | |||
* Usually shows progression to astrocytoma IDH mutant, grade 4. | |||
{{Main|Diffuse astrocytoma}} | {{Main|Diffuse astrocytoma}} | ||
== | ===Astrocytoma, IDH mutant grade 3=== | ||
* Grade III | * Formerly designated Anaplastic astrocytoma Grade III. | ||
* Typically seen in adults. | |||
* Increased cellularity, cell atypia and mitotic activity. | |||
* Lacks endothelial proliferations and necrosis of glioblastoma. | * Lacks endothelial proliferations and necrosis of glioblastoma. | ||
{{Main|Anaplastic astrocytoma}} | {{Main|Anaplastic astrocytoma}} | ||
===Astrocytoma, IDH mutant grade 4=== | |||
* Formerly called Glioblastoma, IDH mutant. | |||
* Endothelial proliferations and necrosis indistinguishable from glioblastoma. | |||
* Homozygous CDKN2A deletion qualifies grade 2 and grade 3 astrocytomas as grade 4 tumor. | |||
==Glioblastoma== | ==Glioblastoma== | ||