48,830
edits
Difference between revisions of "Clear cell papillary renal cell tumour"
Jump to navigation
Jump to search
Clear cell papillary renal cell tumour (view source)
Revision as of 20:53, 21 December 2020
, 20:53, 21 December 2020→See also: +SO
(→IHC) |
(→See also: +SO) |
||
| Line 101: | Line 101: | ||
*''Clear cell'' RCC: CK7 negative. In this tumour it is the opposite - CK7 is positive. | *''Clear cell'' RCC: CK7 negative. In this tumour it is the opposite - CK7 is positive. | ||
*''Papillary'' RCC: AMACR positive. In this tumour it is the opposite - AMACR is negative. | *''Papillary'' RCC: AMACR positive. In this tumour it is the opposite - AMACR is negative. | ||
==Sign out== | |||
<pre> | |||
Left Kidney Mass, Core Biopsy: | |||
- CLEAR CELL TUBULOPAPILARY RENAL CELL CARCINOMA (clear cell | |||
papillary renal cell carcinoma), preliminary ISUP nucleolar | |||
grade 1 of 4, see comment. | |||
Comment: | |||
The tumour has a tubulocystic architecture and is composed of cuboidal cells with clear cytoplasm. The nuclei are reverse stratified. | |||
The tumour stains as follows: | |||
POSITIVE: PAX8 (diffuse), CK7 (strong, diffuse), CK34betaE12 (strong, diffuse), vimentin (diffuse, strong), EMA (moderately, diffuse). | |||
NEGATIVE: CD10. | |||
The findings are in keeping with clear cell tubulopapillary renal cell carcinoma. | |||
These tumours have a highly favourable clinical behaviour.[1,2] The terms "clear cell papillary neoplasm of low malignant potential"[1] and "clear cell papillary (cyst)adenoma"[2] have been proposed as names that better reflect their biology. | |||
1. Pathology. 2020 Nov 19;S0031-3025(20)30957-0. DOI: 10.1016/j.pathol.2020.10.002 | |||
2. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513 | |||
</pre> | |||
==See also== | ==See also== | ||