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** BCOR-positive IHC: ''HGNET BCOR‐altered neuroepithelial tumours'' | ** BCOR-positive IHC: ''HGNET BCOR‐altered neuroepithelial tumours'' | ||
Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal | | Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal |authors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M |title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs |journal=Cell |volume=164 |issue=5 |pages=1060–1072 |date=February 2016 |pmid=26919435 |pmc=5139621 |doi=10.1016/j.cell.2016.01.015 |url=}}</ref> | ||
==Histology== | ==Histology== | ||
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* CK may be focally +ve. | * CK may be focally +ve. | ||
HGNET-BCOR <ref>{{cite journal | | HGNET-BCOR <ref>{{cite journal |authors=Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA |title=High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis |journal=Brain Pathol. |volume=30 |issue=1 |pages=46–62 |date=January 2020 |pmid=31104347 |doi=10.1111/bpa.12747 |url=}}</ref> | ||
* OLIG variable +ve. | * OLIG variable +ve. | ||
* BCOR +ve. | * BCOR +ve. |
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