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Difference between revisions of "Crizotinib"
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*[[Lung carcinoma with ALK rearrangement]].<ref>{{Cite journal | last1 = Wu | first1 = YL. | last2 = Lu | first2 = S. | last3 = Lu | first3 = Y. | last4 = Zhou | first4 = J. | last5 = Shi | first5 = YK. | last6 = Sriuranpong | first6 = V. | last7 = Ho | first7 = JCM. | last8 = Ong | first8 = CK. | last9 = Tsai | first9 = CM. | title = Results of PROFILE 1029, a Phase III Comparison of First-Line Crizotinib versus Chemotherapy in East Asian Patients with ALK-Positive Advanced Non-Small Cell Lung Cancer. | journal = J Thorac Oncol | volume = | issue = | pages = | month = Jun | year = 2018 | doi = 10.1016/j.jtho.2018.06.012 | PMID = 29966800 }}</ref> | *[[Lung carcinoma with ALK rearrangement]].<ref>{{Cite journal | last1 = Wu | first1 = YL. | last2 = Lu | first2 = S. | last3 = Lu | first3 = Y. | last4 = Zhou | first4 = J. | last5 = Shi | first5 = YK. | last6 = Sriuranpong | first6 = V. | last7 = Ho | first7 = JCM. | last8 = Ong | first8 = CK. | last9 = Tsai | first9 = CM. | title = Results of PROFILE 1029, a Phase III Comparison of First-Line Crizotinib versus Chemotherapy in East Asian Patients with ALK-Positive Advanced Non-Small Cell Lung Cancer. | journal = J Thorac Oncol | volume = | issue = | pages = | month = Jun | year = 2018 | doi = 10.1016/j.jtho.2018.06.012 | PMID = 29966800 }}</ref> | ||
*Lung carcinoma with MET amplification.<ref>{{Cite journal | last1 = Forde | first1 = PM. | last2 = Rudin | first2 = CM. | title = Crizotinib in the treatment of non-small-cell lung cancer. | journal = Expert Opin Pharmacother | volume = 13 | issue = 8 | pages = 1195-201 | month = Jun | year = 2012 | doi = 10.1517/14656566.2012.688029 | PMID = 22594847 }}</ref> | *Lung carcinoma with MET amplification.<ref>{{Cite journal | last1 = Forde | first1 = PM. | last2 = Rudin | first2 = CM. | title = Crizotinib in the treatment of non-small-cell lung cancer. | journal = Expert Opin Pharmacother | volume = 13 | issue = 8 | pages = 1195-201 | month = Jun | year = 2012 | doi = 10.1517/14656566.2012.688029 | PMID = 22594847 }}</ref> | ||
Crizotinib has been largely subplanted by a new generation of ALK inhibitors that were designed to cross the blood-brain barrier.<ref name=pmid31331844>{{Cite journal | last1 = Wrona | first1 = A. | title = Management of CNS disease in ALK-positive non-small cell lung cancer: Is whole brain radiotherapy still needed? | journal = Cancer Radiother | volume = 23 | issue = 5 | pages = 432-438 | month = Sep | year = 2019 | doi = 10.1016/j.canrad.2019.03.009 | PMID = 31331844 }}</ref> | |||
==See also== | ==See also== | ||