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'''Syphilis''' is the infectious disease caused by ''Treponema pallidum''. | '''Syphilis''' is the infectious disease caused by ''Treponema pallidum''. | ||
==General== | |||
*Classically affects the [[testis]] before the epididymis.<ref name=Ref_WMSP364>{{Ref WMSP|364}}</ref> | |||
**[[Tuberculosis]]<ref name=pmid19468469>{{Cite journal | last1 = Das | first1 = P. | last2 = Ahuja | first2 = A. | last3 = Gupta | first3 = SD. | title = Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited. | journal = Indian J Urol | volume = 24 | issue = 3 | pages = 356-61 | month = Jul | year = 2008 | doi = 10.4103/0970-1591.42618 | PMID = 19468469 }}</ref> and gonorrhea usually affect the epididymis before the testis. | |||
*Considered one of the [[TORCH infections]]. | |||
==Gross== | |||
Aorta: | |||
*Wrinkled intimal surface - "tree bark" appearance.<ref>{{Ref AoGP|80}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *[[Plasma cells]] - '''key feature'''.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | ||
* | *Spirochetes - '''diagnostic'''. | ||
*+/-[[Granulomas]]<ref name=Ref_PCPBoD8_47>{{Ref PCPBoD8|47}}</ref> - ''gumma'' - in the tertiary phase.<ref>URL: [http://pediatrics.aappublications.org/cgi/content/full/104/1/e4 http://pediatrics.aappublications.org/cgi/content/full/104/1/e4]. Accessed on: 17 November 2010.</ref> | |||
DDx: | |||
*[[Plasma cell neoplasm]]. | |||
*Reactive changes. | |||
*[[Zoon balanitis]]. | |||
*Other spirochetes, e.g. ''Borrelia burgdorferi''. | |||
==[[Stains]]== | |||
*Dieterle stain. | *[[Dieterle stain]]. | ||
Image | ===Image=== | ||
<gallery> | |||
Image:Treponema_pallidum_-_very_high_mag_-_extreme_crop.jpg | T. pallidum - very high mag. cropped. [[Dieterle stain]]. (WC) | |||
Image:Treponema_pallidum_-_very_high_mag.jpg | T. pallidum - very high mag. [[Dieterle stain]]. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
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*[[Microorganisms]]. | *[[Microorganisms]]. | ||
*[[Intestinal spirochetosis]]. | *[[Intestinal spirochetosis]]. | ||
*[[Inflammatory skin disorders]]. | |||
*[[Granulomatous orchitis]]. | |||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||
[[Category:Diagnosis]] |
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