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Difference between revisions of "Neurodegenerative diseases"
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tdp wikify
Jensflorian (talk | contribs) (→Images: images added) |
Jensflorian (talk | contribs) (tdp wikify) |
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TDP-43 proteinopathies: | TDP-43 proteinopathies: | ||
*[[Amyotrophic lateral sclerosis]]. | *[[Amyotrophic lateral sclerosis]]. | ||
*Frontotemporal lobar degeneration. | *Frontotemporal lobar degeneration (FTLD TDP-43). | ||
FUS proteinopathies: | FUS proteinopathies: | ||
| Line 90: | Line 90: | ||
|- | |- | ||
| [[Amyotrophic lateral sclerosis|Amyotrophic lateral <br>sclerosis (ALS)]] | | [[Amyotrophic lateral sclerosis|Amyotrophic lateral <br>sclerosis (ALS)]] | ||
| TDP-43 | | [[TDP-43]] | ||
| motor neurons | | motor neurons | ||
| spasticity, weakness | | spasticity, weakness | ||
| Line 97: | Line 97: | ||
|- | |- | ||
| Frontotemporal lobar <br>degeneration with TDP-43 (FTLD-TDP) | | Frontotemporal lobar <br>degeneration with TDP-43 (FTLD-TDP) | ||
| TDP-43 | | [[TDP-43]] | ||
| cortex, basal ganglia | | cortex, basal ganglia | ||
| dementia, focal cortical syndromes | | dementia, focal cortical syndromes | ||
| histology depends on (type 1-4), ubiquitin and TDP-43+ve, tau and FUS-ve | | histology depends on (type 1-4), ubiquitin and [[TDP-43]]+ve, tau and FUS-ve | ||
| [https://commons.wikimedia.org/wiki/File:FTLD_TSP43_hippocampus.jpg] | | [https://commons.wikimedia.org/wiki/File:FTLD_TSP43_hippocampus.jpg] | ||
|- | |- | ||
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===Tau=== | ===Tau=== | ||
*AT8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | *AT8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, [[TDP-43]]-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | ||
**''AT'' = anti-tau. | **''AT'' = anti-tau. | ||
**Stains tau 4R and tau 3R.<ref>{{cite journal |author=Kumaran R, Kingsbury A, Coulter I, ''et al.'' |title=DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders |journal=Neurobiol. Dis. |volume=28 |issue=1 |pages=122–32 |year=2007 |month=October |pmid=17719794 |doi=10.1016/j.nbd.2007.07.012 |url=}}</ref> | **Stains tau 4R and tau 3R.<ref>{{cite journal |author=Kumaran R, Kingsbury A, Coulter I, ''et al.'' |title=DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders |journal=Neurobiol. Dis. |volume=28 |issue=1 |pages=122–32 |year=2007 |month=October |pmid=17719794 |doi=10.1016/j.nbd.2007.07.012 |url=}}</ref> | ||