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Difference between revisions of "Leukemia"
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add to list of leukemias
(some rearranging + classification) |
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*Lymphoma = discrete mass(es), usu. [[lymph node]]. | *Lymphoma = discrete mass(es), usu. [[lymph node]]. | ||
**Classic presentation: non-tender lymph nodes | **Classic presentation: non-tender lymph nodes | ||
Most leukemias are typically classified into acute or chronic. As a general rule, the designation of '''acute''' signifies a more immature and aggressive phenotype, whilst '''[[chronic]]''' leukemias generally show a more differentiated phenotype and run a more indolent course. There are exceptions, of course, and some chronic leukemias may transform into acute lymphomas. | |||
=Definition= | =Definition= | ||
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#Morphologic abnormalities. | #Morphologic abnormalities. | ||
#>20% blasts ''or'' recurrent cytogenetic abnormality. | #>20% blasts ''or'' recurrent cytogenetic abnormality. | ||
=Leukemia classification= | =Leukemia classification= | ||
*[[Acute myeloid leukemia]] (AML): | *[[Acute myeloid leukemia]] (AML): | ||
*#AML. | *#AML. | ||
*#AML with recurrent cytogenetic abnormalities. | *#AML with recurrent cytogenetic abnormalities, e.g. | ||
*#AML from [[MDS]]. | **#t(8;21). | ||
**#inv(16). | |||
**#t(15;17). | |||
*#AML arising from [[MDS]]. | |||
*#AML in the setting of [[Down syndrome]]. | *#AML in the setting of [[Down syndrome]]. | ||
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*#T cell (sometimes abbreviated to T-ALL) | *#T cell (sometimes abbreviated to T-ALL) | ||
* | *T-ALL should not to be confused with [[adult T-cell leukemia/lymphoma]] (ATLL) | ||
*[[Chronic lymphocytic leukemia]] (CLL) - usually classified with lymphomas | |||
A few fall under the umbrella of '''[[myeloproliferative neoplasm]]s''': | |||
*[[Chronic myeloid leukemia]] (CML) | *[[Chronic myeloid leukemia]] (CML) | ||
*[[Chronic | *[[Chronic neutrophilic leukemia]] | ||
*[[Chronic eosinophilic leukemia]] | |||
And others under the myeloproliferative/myelodysplastic overlap syndromes: | |||
*[[Chronic myelomonocytic leukemia]] | |||
Rarer leukemias: | Other Rarer leukemias: | ||
*Plasma cell leukaemia | *Plasma cell leukaemia | ||
*Mast cell leukemia | *Mast cell leukemia | ||