Difference between revisions of "Myeloproliferative neoplasms"

Myeloproliferative neoplasms (view source)

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 ==Clinic==
-* moderate to severe anemia (in cases where the erythrocytosis is not a feature)
+* increase in blood count(s), dependent on type of MPN
+* anemia may occur in late stage disease or due leukemic transformation
 * pale skin
 * fatigue
-* prolonged bleeding
 * enlarged spleen
-* increased clotting
+* increased clotting (i.e. thrombosis)
 ==Polycythemia vera==
@@ Line 24: / Line 24: @@
 *Typical course:
 **Prodromal stadium: Mild erythrocytosis.
-**Polycythemic phase: Incereased RBC count.
+**Polycythemic phase: Increased RBC count.
 **Post-polycythemic ("spent") phase: Ineffective hematopoiesis, bone marrow fibrosis.
-*Transformation in [[AML]] possible (2-3%).
+*Transformation to [[AML]] possible (2-3%).
 ===Morphology===
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 *Many megakaryocytes in bone marrow section.
 *Increased cellularity of bone marrow (35-100%).
-*Teardrop-RBC cells (dacryocytes) in late stage.
+*Teardrop-RBC cells (dacrocytes) in late stage.
 *Fibrosis (reticulin stain).
@@ Line 39: / Line 39: @@
 *Median age: 55 years.
 *Mostly asymptomatic.
-*Indolent course, long-term survival. Life-threatening thromboembolitic epsisodes.
+*Indolent course, long-term survival. Life-threatening thromboembolic epsisodes.
 ===Morphology===
 *Thrombocytosis.
 *Bone marrow normo- to slightly hypercellular.
-*Large megakaryocytes in bone-marrow.
+*Large hypersegmented megakaryocytes in bone-marrow.
 *Usually no BM fibrosis.