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Difference between revisions of "Myeloproliferative neoplasms"
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MPN vs MDS
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'''Myeloproliferative neoplasms''', also '''myeloproliferative disorders''', are a group of indolent hematologic neoplasms characterized by clonal expansion of pluripotent hematopoietic progenitor. | '''Myeloproliferative neoplasms''', also '''myeloproliferative disorders''', are a group of indolent hematologic neoplasms characterized by clonal expansion of pluripotent hematopoietic progenitor. | ||
These should '''not''' be confused with ''[[myelodysplastic syndromes]]'' (MDS). | These should '''not''' be confused with ''[[myelodysplastic syndromes]]'' (MDS), the main difference is that MPNs produce functional haematological cells detectable on a complete blood count, whereas in MDS, hematopoisis is ineffective and is characterised by cytopenias. | ||
==Grouping== | ==Grouping== | ||
They include the following:<ref name=pmid15781101>{{cite journal |author=Baxter EJ, Scott LM, Campbell PJ, ''et al.'' |title=Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders |journal=Lancet |volume=365 |issue=9464 |pages=1054–61 |year=2005 |pmid=15781101 |doi=10.1016/S0140-6736(05)71142-9 |url=}}</ref> | They include the following:<ref name=pmid15781101>{{cite journal |author=Baxter EJ, Scott LM, Campbell PJ, ''et al.'' |title=Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders |journal=Lancet |volume=365 |issue=9464 |pages=1054–61 |year=2005 |pmid=15781101 |doi=10.1016/S0140-6736(05)71142-9 |url=}}</ref> | ||
*Polycythemia vera | *[[Chronic myeloid leukemia]] | ||
*Essential thrombocythemia. | *[[Polycythemia vera]] | ||
*Idiopathic myelofibrosis. | *[[Essential thrombocythemia]]. | ||
*[[Idiopathic myelofibrosis]]. | |||
==Clinic== | ==Clinic== | ||
* moderate to severe anemia | * moderate to severe anemia (in cases where the erythrocytosis is not a feature) | ||
* pale skin | * pale skin | ||
* fatigue | * fatigue | ||