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Difference between revisions of "Astrocytoma"
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→Gliomatosis cerebri
Jensflorian (talk | contribs) (→Diffuse midline glioma, H3 K27M mutant: update) |
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{{Main|Pleomorphic xanthoastrocytoma}} | {{Main|Pleomorphic xanthoastrocytoma}} | ||
=Gliomatosis cerebri= | |||
* | * Depreceated entity. | ||
* Was used for extensively diffusely growing astrocytic neoplasms. | |||
**Introduced in 1938 as a post-mortem diagnosis.<ref>SAMUEL NEVIN - GLIOMATOSIS CEREBRI, DOI: http://dx.doi.org/10.1093/brain/61.2.170 170-191 First published online: 1 June 1938</ref> | **Introduced in 1938 as a post-mortem diagnosis.<ref>SAMUEL NEVIN - GLIOMATOSIS CEREBRI, DOI: http://dx.doi.org/10.1093/brain/61.2.170 170-191 First published online: 1 June 1938</ref> | ||
**Since 2016 it is no longer considered a distinct entity.<ref>{{Cite journal | last1 = Johnson | first1 = DR. | last2 = Guerin | first2 = JB. | last3 = Giannini | first3 = C. | last4 = Morris | first4 = JM. | last5 = Eckel | first5 = LJ. | last6 = Kaufmann | first6 = TJ. | title = 2016 Updates to the WHO Brain Tumor Classification System: What the Radiologist Needs to Know. | journal = Radiographics | volume = 37 | issue = 7 | pages = 2164-2180 | month = | year = | doi = 10.1148/rg.2017170037 | PMID = 29028423 }}</ref><ref>{{Cite journal | last1 = Herrlinger | first1 = U. | last2 = Jones | first2 = DT. | last3 = Glas | first3 = M. | last4 = Hattingen | first4 = E. | last5 = Gramatzki | first5 = D. | last6 = Stuplich | first6 = M. | last7 = Felsberg | first7 = J. | last8 = Bähr | first8 = O. | last9 = Gielen | first9 = GH. | title = Gliomatosis cerebri: no evidence for a separate brain tumor entity. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Oct | year = 2015 | doi = 10.1007/s00401-015-1495-z | PMID = 26493382 }}</ref> | |||
* More than 3 lobes have to be involved, us. bilateral (radiology required). | * More than 3 lobes have to be involved, us. bilateral (radiology required). | ||
* biologic behaviour corresponds to WHO III (ICD-O: 9381/3) | * biologic behaviour corresponds to WHO III (ICD-O: 9381/3) | ||
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** GC type 2: with a solid portion, mostly IDH1 mutant. | ** GC type 2: with a solid portion, mostly IDH1 mutant. | ||
* Genetic studies indicate strong overlap with diffuse astrocytic gliomas, oligodendrogliomas and glioblastoma. | * Genetic studies indicate strong overlap with diffuse astrocytic gliomas, oligodendrogliomas and glioblastoma. | ||
==Diffuse midline glioma, H3 K27M mutant== | ==Diffuse midline glioma, H3 K27M mutant== | ||