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Difference between revisions of "Lung carcinoma with ALK rearrangement"
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Lung carcinoma with ALK rearrangement (view source)
Revision as of 01:14, 28 September 2017
, 01:14, 28 September 2017→Molecular
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==Molecular== | ==Molecular== | ||
*EML4-ALK fusion -- inv(2)(p21p23).<ref name=pmid21245935>{{Cite journal | last1 = Li | first1 = Y. | last2 = Ye | first2 = X. | last3 = Liu | first3 = J. | last4 = Zha | first4 = J. | last5 = Pei | first5 = L. | title = Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors. | journal = Neoplasia | volume = 13 | issue = 1 | pages = 1-11 | month = Jan | year = 2011 | doi = | PMID = 21245935 }}</ref> | *EML4-ALK fusion -- inv(2)(p21p23).<ref name=pmid21245935>{{Cite journal | last1 = Li | first1 = Y. | last2 = Ye | first2 = X. | last3 = Liu | first3 = J. | last4 = Zha | first4 = J. | last5 = Pei | first5 = L. | title = Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors. | journal = Neoplasia | volume = 13 | issue = 1 | pages = 1-11 | month = Jan | year = 2011 | doi = | PMID = 21245935 }}</ref> | ||
**C-terminus of ALK protein fuses with N-terminus portion of partner protein. | |||
***ALK fusion leads to ligand-independent constitutive activation of important pathways in oncogenesis and tumor progression. | |||
Notes: | Notes: | ||