Difference between revisions of "Lung carcinoma with ALK rearrangement"

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**Can be treated with ''[[crizotinib]]''.<ref name=pmid21475126>{{Cite journal  | last1 = Crystal | first1 = AS. | last2 = Shaw | first2 = AT. | title = New targets in advanced NSCLC: EML4-ALK. | journal = Clin Adv Hematol Oncol | volume = 9 | issue = 3 | pages = 207-14 | month = Mar | year = 2011 | doi =  | PMID = 21475126 }}</ref>
**Can be treated with ''[[crizotinib]]''.<ref name=pmid21475126>{{Cite journal  | last1 = Crystal | first1 = AS. | last2 = Shaw | first2 = AT. | title = New targets in advanced NSCLC: EML4-ALK. | journal = Clin Adv Hematol Oncol | volume = 9 | issue = 3 | pages = 207-14 | month = Mar | year = 2011 | doi =  | PMID = 21475126 }}</ref>
***Resistance to ALK inhibitors may occur due mutations in kinase domain.
***Resistance to ALK inhibitors may occur due mutations in kinase domain.
***Ceritinib is indicated for tumor with acquired resistance to crizotinib.<ref name="pmid24670165">{{Cita publicación | apellido = Shaw | nombre = AT. | coautores = DW. Kim, R. Mehra, DS. Tan, E. Felip, LQ. Chow, DR. Camidge, J. Vansteenkiste, S. Sharma, T. De Pas, GJ. Riely | título = Ceritinib in ALK-rearranged non-small-cell lung cancer. | publicación = N Engl J Med | volume = 370 | número = 13 | páginas = 1189-97 | mes = Mar | año = 2014 | doi = 10.1056/NEJMoa1311107 | pmid = 24670165 }}</ref>
***Ceritinib is indicated for tumor with acquired resistance to crizotinib.<ref>{{Cite journal | last1 = Shaw | first1 = AT. | last2 = Kim | first2 = DW. | last3 = Mehra | first3 = R. | last4 = Tan | first4 = DS. | last5 = Felip | first5 = E. | last6 = Chow | first6 = LQ. | last7 = Camidge | first7 = DR. | last8 = Vansteenkiste | first8 = J. | last9 = Sharma | first9 = S. | title = Ceritinib in ALK-rearranged non-small-cell lung cancer. | journal = N Engl J Med | volume = 370 | issue = 13 | pages = 1189-97 | month = Mar | year = 2014 | doi = 10.1056/NEJMoa1311107 | PMID = 24670165 }}</ref>


==Microscopic==
==Microscopic==
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