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'''Hyalinizing trabecular tumour''', abbreviated '''HTT''', is a rare tumour of the [[thyroid glands]]. It is also known as '''hyalinizing trabecular adenoma'''. | |||
==General== | |||
*Considered by some to be a variant of [[papillary thyroid carcinoma]].<ref name=pmid11117782>{{cite journal |author=Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL |title=Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics |journal=Am. J. Surg. Pathol. |volume=24 |issue=12 |pages=1622–6 |year=2000 |month=December |pmid=11117782 |doi= |url=}}</ref> | |||
*Behaviour similar to papillary thyroid carcinoma - indolent. | |||
==Microscopic== | |||
Features: | |||
*Trabecular arrangement of cells. | |||
**May have "curved" trabeculae. | |||
*Extracellular space has hyaline material - '''key feature'''. | |||
*Cytoplasm mimics hyaline material in the extracellular space. | |||
DDx: | |||
*[[Papillary thyroid carcinoma]] (if one believes this is a separate entity). | |||
*[[Medullary thyroid carcinoma]] - not trabecular, nuclei not [[PTC]]-like. | |||
*[[Paraganglioma]].<ref>URL: [http://path.upmc.edu/cases/case465/dx.html http://path.upmc.edu/cases/case465/dx.html]. Accessed on: 17 January 2011.</ref> | |||
===Images=== | |||
<gallery> | |||
Image: Hyalinized trabecular tumour - low mag.jpg | HHT - low mag. (WC) | |||
Image: Hyalinized trabecular tumour - intermed mag.jpg | HHT - intermed. mag. (WC) | |||
Image: Hyalinized trabecular tumour - high mag.jpg | HHT - high mag. (WC) | |||
Image: Thyroid gland - high mag.jpg | Thyroid gland - high mag. (WC) | |||
Image: Hyalinized trabecular tumour - 2 - intermed mag.jpg | HHT - intermed. mag. (WC) | |||
Image: Hyalinized trabecular tumour - 2 - high mag.jpg | HHT - high mag. (WC) | |||
Image: Hyalinized trabecular tumour - 3 - intermed mag.jpg | HHT - intermed. mag. (WC) | |||
Image: Hyalinized trabecular tumour - 3 - high mag.jpg | HHT - high mag. (WC) | |||
Image: Hyalinized trabecular tumour - 3 - very high mag.jpg | HHT - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://archive.biomedcentral.com/1742-6413/3/17/figure/F2?highres=y HTT (biomedcentral.com)].<ref name=pmid16867191>{{Cite journal | last1 = Baloch | first1 = ZW. | last2 = Puttaswamy | first2 = K. | last3 = Brose | first3 = M. | last4 = LiVolsi | first4 = VA. | title = Lack of BRAF mutations in hyalinizing trabecular neoplasm. | journal = Cytojournal | volume = 3 | issue = | pages = 17 | month = | year = 2006 | doi = 10.1186/1742-6413-3-17 | PMID = 16867191 }}</ref> | |||
*[http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.article-g01.fs.jpg HTT (ispub.com)].<ref>URL: [http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html]. Accessed on: 1 January 2012.</ref> | |||
==IHC== | |||
*Thyroglobulin +ve. | |||
*NSE +ve. | |||
*[[Ki-67 membranous pattern]].<ref name=pmid17525638>{{Cite journal | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref> | |||
==See also== | |||
*[[Thyroid gland]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Endocrine pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||