Difference between revisions of "Muscularis propria invasion in the urinary bladder"

Muscularis propria invasion in the urinary bladder (view source)

1,343 bytes added , 15:34, 27 January 2017

+IHC section

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 Image: Muscle invasive urothelial carcinoma -- high mag.jpg | MIUC - high mag.
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+==IHC==
+''Smoothelin'' [[immunostain]]:<ref name=pmid18936687>{{Cite journal  | last1 = Paner | first1 = GP. | last2 = Shen | first2 = SS. | last3 = Lapetino | first3 = S. | last4 = Venkataraman | first4 = G. | last5 = Barkan | first5 = GA. | last6 = Quek | first6 = ML. | last7 = Ro | first7 = JY. | last8 = Amin | first8 = MB. | title = Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 1 | pages = 91-8 | month = Jan | year = 2009 | doi = 10.1097/PAS.0b013e3181804727 | PMID = 18936687 }}</ref>
+*Muscularis propria - usu. strong. †
+*Muscularis mucosae - negative/weak. †
+Note:
+*† Overlap between the patterns is described,<ref name=pmid20154589>{{Cite journal  | last1 = Miyamoto | first1 = H. | last2 = Sharma | first2 = RB. | last3 = Illei | first3 = PB. | last4 = Epstein | first4 = JI. | title = Pitfalls in the use of smoothelin to identify muscularis propria invasion by urothelial carcinoma. | journal = Am J Surg Pathol | volume = 34 | issue = 3 | pages = 418-22 | month = Mar | year = 2010 | doi = 10.1097/PAS.0b013e3181ce5066 | PMID = 20154589 }}</ref> this limits the utility of the immunostain.
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