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Difference between revisions of "P40"
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'''p40''' an [[immunostain]] that is both [[sensitive and specific]] for [[squamous cell carcinoma]]. | '''p40''' an [[immunostain]] that is both [[sensitivity|sensitive]] and [[specificity|specific]] for [[squamous cell carcinoma]]. | ||
==General== | ==General== | ||
*Considered superior to [[p63]] as it is more [[specific]].<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref> | *Considered superior to [[p63]] as it is more [[specificity|specific]].<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref> | ||
**p63 stains a significant number of adenocarcinoma. | **p63 stains a significant number of adenocarcinoma. | ||
==Positive== | ==Staining== | ||
===Positive=== | |||
*[[Squamous cell carcinoma of the lung]]. | *[[Squamous cell carcinoma of the lung]]. | ||
==Negative== | ===Negative=== | ||
*[[Lung adenocarcinoma]]. | *[[Lung adenocarcinoma]]. | ||