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Difference between revisions of "NSAID enteropathy"
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'''NSAID enteropathy''' is inflammation of the [[small intestine]] due to a [[Non-steroidal anti-inflammatory drug (NSAID)]]. | '''NSAID enteropathy''' is inflammation of the [[small intestine]] due to a [[Non-steroidal anti-inflammatory drug|non-steroidal anti-inflammatory drug (NSAID)]]. | ||
==General== | ==General== | ||
*[[Clinical diagnosis]]. | *[[Clinical diagnosis]]. | ||
*NSAID use - such as in [[rheumatoid arthritis]] or [[osteoarthritis]].<ref>{{Cite journal | last1 = Tachecí | first1 = I. | last2 = Bradna | first2 = P. | last3 = Douda | first3 = T. | last4 = Baštecká | first4 = D. | last5 = Kopáčová | first5 = M. | last6 = Rejchrt | first6 = S. | last7 = Lutonský | first7 = M. | last8 = Soukup | first8 = T. | last9 = Bureš | first9 = J. | title = Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis. | journal = Rheumatol Int | volume = 36 | issue = 11 | pages = 1557-1561 | month = Nov | year = 2016 | doi = 10.1007/s00296-016-3552-x | PMID = 27549792 }}</ref> | *NSAID use - such as in [[rheumatoid arthritis]] or [[osteoarthritis]].<ref>{{Cite journal | last1 = Tachecí | first1 = I. | last2 = Bradna | first2 = P. | last3 = Douda | first3 = T. | last4 = Baštecká | first4 = D. | last5 = Kopáčová | first5 = M. | last6 = Rejchrt | first6 = S. | last7 = Lutonský | first7 = M. | last8 = Soukup | first8 = T. | last9 = Bureš | first9 = J. | title = Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis. | journal = Rheumatol Int | volume = 36 | issue = 11 | pages = 1557-1561 | month = Nov | year = 2016 | doi = 10.1007/s00296-016-3552-x | PMID = 27549792 }}</ref> | ||
*The pathobiology of NSAID enteropathy in the distal small bowel (ileum) is thought to be different than NSAID induced injury in the stomach and duodenum. | |||
**Enterohepatic recirculation (absorbed NSAID excreted via bile) is thought to play a role.<ref name=pmid21627632 >{{Cite journal | last1 = Wallace | first1 = JL. | title = NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies. | journal = Br J Pharmacol | volume = 165 | issue = 1 | pages = 67-74 | month = Jan | year = 2012 | doi = 10.1111/j.1476-5381.2011.01509.x | PMID = 21627632 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||