NSAID enteropathy

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NSAID enteropathy is inflammation of the small intestine due to a non-steroidal anti-inflammatory drug (NSAID).


  • Clinical diagnosis.
  • NSAID use - such as in rheumatoid arthritis or osteoarthritis.[1]
  • The pathobiology of NSAID enteropathy in the distal small bowel (ileum) is thought to be different than NSAID induced injury in the stomach and duodenum.
    • Enterohepatic recirculation (absorbed NSAID excreted via bile) is thought to play a role.[2]


See Ileitis.



  1. Tachecí, I.; Bradna, P.; Douda, T.; Baštecká, D.; Kopáčová, M.; Rejchrt, S.; Lutonský, M.; Soukup, T. et al. (Nov 2016). "Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis.". Rheumatol Int 36 (11): 1557-1561. doi:10.1007/s00296-016-3552-x. PMID 27549792.
  2. Wallace, JL. (Jan 2012). "NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies.". Br J Pharmacol 165 (1): 67-74. doi:10.1111/j.1476-5381.2011.01509.x. PMID 21627632.
  3. Dilauro, S.; Crum-Cianflone, NF. (Aug 2010). "Ileitis: when it is not Crohn's disease.". Curr Gastroenterol Rep 12 (4): 249-58. doi:10.1007/s11894-010-0112-5. PMID 20532706.