Difference between revisions of "Vasculitides"

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Vasculitides (view source)

Revision as of 16:53, 31 August 2016

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→‎Wegener granulomatosis: split
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*[http://path.upmc.edu/cases/case260/micro.html Microscopic polyangiitis - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case260/micro.html Microscopic polyangiitis - several images (upmc.edu)].


==Wegener granulomatosis==
==Granulomatosis with polyangiitis==
*Abbreviated ''WG''.
*[[AKA]] ''Wegener granulomatosis''.
*[[AKA]] ''granulomatosis with polyangiitis''.
{{Main|Granulomatosis with polyangiitis}}
===General===
*Autoimmune.
 
====Clinical====
*Epistasis.
*Renal failure - present as ''nephritic syndrome''.
**Renal biopsy: crescentic glomerulonephritis ([[AKA]] [[rapidly progressive glomerulonephritis]]).
*[[Pulmonary hemorrhage]].
 
Serology:
*c-ANCA +ve.<ref name=Ref_TN2005_RH6>{{Ref TN2005|RH6}}</ref>
 
Notes:
*Pulmonary hemorrhage syndromes:<ref name=Ref_PBoD745>{{Ref PBoD|745}}</ref>
**[[Goodpasture syndrome]].
**Idiopathic pulmonary hemosiderosis.
**Vasculitis-assoc. hemorrhage (hypersensitivity angiitis, Wegener granulomatosis).
**[[Systemic lupus erythematosus]].
 
===Microscopic===
Features:
*Small vessel vasculitis:
*#Inflammatory cells within the vessel wall.
*#*[[Granuloma]]s - typically poorly formed.<ref name=Ref_PBoD747>{{Ref PBoD|747}}</ref>
*#**Multinucleated giant cells - common. (???)
*#Vessel wall injury.
*#*[[Fibrinoid necrosis]].
 
Notes:
*In the lung, the [[granuloma]]s tend to be centrilobular, as the artery travels with the airway and is centrilobular.
**It may difficult to find small blood vessels in affected portions of lung.
 
====Images====
<gallery>
Image:Wegener's granulomatosis - intermed mag.jpg | WG - intermed. mag. (WC)
Image:Wegener's granulomatosis - very high mag.jpg | WG - very high mag. (WC)
Image:Wegener's granulomatosis -b- intermed mag.jpg | WG - intermed. mag. (WC)
Image:Wegener's granulomatosis -b- high mag.jpg | WG - high mag. (WC)
Image:Wegener's granulomatosis -b- very high mag.jpg | WG - very high mag. (WC)
</gallery>
www:
*[http://www.flickr.com/photos/pulmonary_pathology/3734403695/ Wegener's granulomatosis (flickr.com)].
*[http://path.upmc.edu/cases/case269.html Wegener's granulomatosis - several crappy images (upmc.edu)].
*[http://path.upmc.edu/cases/case660.html Wegener's granulomatosis - more crappy images (upmc.edu)].
*[http://path.upmc.edu/cases/case675.html WG - more images (upmc.edu)].


==Churg-Strauss syndrome==
==Churg-Strauss syndrome==
Michael
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