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| ==Small vessel leukocytoclastic vasculitis== | | ==Small vessel leukocytoclastic vasculitis== |
| *[[AKA]] ''leukocytoclastic vasculitis'', abbreviated ''LCV''. | | *[[AKA]] ''leukocytoclastic vasculitis'', abbreviated ''LCV''. |
| | | {{Main|Small vessel leukocytoclastic vasculitis}} |
| ===General===
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| *Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref>
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| Clinical:
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| *Palpable purpura, usu. lower extremity.
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| ===Microscopic===
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| Features:<ref name=pmid18948765/>
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| *Small upper dermis vessels with:
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| *#Neutrophils.
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| *#*Fragmentation of neutrophils (leukocytoclasia).
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| *#Vessel damage: fibrin deposition (bright pink acellular stuff).
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| Has a very broad DDx:<ref name=pmid18948765/>
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| #Infectious:
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| #*Bacterial.
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| #*Viral.
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| #*[[Fungal]].
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| #Vasculitic disorders:
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| #*ANCA mediated vasculitides:
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| #**[[Wegener granulomatosis]].
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| #**[[Churg-Strauss syndrome]].
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| #*[[Henoch–Schönlein purpura]].<ref name=pmid9713395>{{Cite journal | last1 = Kraft | first1 = DM. | last2 = Mckee | first2 = D. | last3 = Scott | first3 = C. | title = Henoch-Schönlein purpura: a review. | journal = Am Fam Physician | volume = 58 | issue = 2 | pages = 405-8, 411 | month = Aug | year = 1998 | doi = | PMID = 9713395 }}</ref>
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| #*Urticarial vasculitis.
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| #Other:
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| #*[[Connective tissue disease]], e.g. [[mixed connective tissue disease]], [[SLE]], [[rheumatoid arthritis]].
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| #*[[Cryoglobulinemia]] - may be due to [[multiple myeloma]], [[hepatitis C]]; have intravascular thrombi.
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| #*Paraneoplastic.
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| #*Drugs.
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| Image:
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| *[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)].
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| *[http://path.upmc.edu/cases/case189.html LCA of the GI tract - several images (upmc.edu)].
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| ===Stains===
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| *PAS - look for fungus.
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| ==Microscopic polyangiitis== | | ==Microscopic polyangiitis== |