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Difference between revisions of "Cystic tumour of the atrioventricular nodal region"
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Cystic tumour of the atrioventricular nodal region (view source)
Revision as of 23:44, 22 July 2016
, 23:44, 22 July 2016no edit summary
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| LMDDx = cystic metastatic [[carcinoma]] | | LMDDx = cystic metastatic [[carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CEA +ve, EMA +ve | | IHC = CEA +ve, EMA +ve, calretinin -ve, WT1 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 17: | Line 17: | ||
| Staging = | | Staging = | ||
| Site = [[heart]] - see ''[[cardiac tumours]]'' | | Site = [[heart]] - see ''[[cardiac tumours]]'' | ||
| Assdx = | | Assdx = [[sudden cardiac death]] | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = usu. women - young | ||
| Signs = | | Signs = conduction abnormalities, +/-bradycardia (due to complete heart block) | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = very rare | | Prevalence = very rare | ||
| Line 28: | Line 28: | ||
| Prognosis = good if caught in time | | Prognosis = good if caught in time | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = other [[cardiac tumours]] | ||
| Tx = excision | | Tx = excision for diagnosis + pacemaker | ||
}} | }} | ||
'''Cystic tumour of the atrioventricular nodal region''', abbreviated '''CTAVNR''', is a rare cardiac tumour that can lead to [[sudden cardiac death]]. | '''Cystic tumour of the atrioventricular nodal region''', abbreviated '''CTAVNR''', is a rare cardiac tumour that can lead to [[sudden cardiac death]]. | ||
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*Very rare.<ref name=pmid11855098>{{Cite journal | last1 = Kaminishi | first1 = Y. | last2 = Watanabe | first2 = Y. | last3 = Nakata | first3 = H. | last4 = Shimokama | first4 = T. | last5 = Jikuya | first5 = T. | title = Cystic tumor of the atrioventricular nodal region. | journal = Jpn J Thorac Cardiovasc Surg | volume = 50 | issue = 1 | pages = 37-9 | month = Jan | year = 2002 | doi = | PMID = 11855098 }}</ref> | *Very rare.<ref name=pmid11855098>{{Cite journal | last1 = Kaminishi | first1 = Y. | last2 = Watanabe | first2 = Y. | last3 = Nakata | first3 = H. | last4 = Shimokama | first4 = T. | last5 = Jikuya | first5 = T. | title = Cystic tumor of the atrioventricular nodal region. | journal = Jpn J Thorac Cardiovasc Surg | volume = 50 | issue = 1 | pages = 37-9 | month = Jan | year = 2002 | doi = | PMID = 11855098 }}</ref> | ||
*May cause [[Sudden_natural_death|sudden cardiac death]].<ref name=pmid10722558/> | *May cause [[Sudden_natural_death|sudden cardiac death]].<ref name=pmid10722558/> | ||
*Antemortem diagnosis | *Antemortem diagnosis extremely rare - only four reported in literature as of 2010.<ref name=pmid19144541>{{Cite journal | last1 = Sharma | first1 = G. | last2 = Linden | first2 = MD. | last3 = Schultz | first3 = DS. | last4 = Inamdar | first4 = KV. | title = Cystic tumor of the atrioventricular node: an unexpected finding in an explanted heart. | journal = Cardiovasc Pathol | volume = 19 | issue = 3 | pages = e75-8 | month = | year = | doi = 10.1016/j.carpath.2008.10.011 | PMID = 19144541 }}</ref> | ||
Clinical: | Clinical:<ref name=pmid19144541/> | ||
*Conduction abnormalities. | *Conduction abnormalities. | ||
**Complete heart block. | **Complete heart block. | ||
*Usually women. | *Usually women - mean age 38 years. | ||
Treatment: | |||
*Excision + pacemaker.<ref name=pmid19237400>{{Cite journal | last1 = Guo | first1 = J. | last2 = Zuo | first2 = S. | last3 = Lin | first3 = C. | last4 = Ji | first4 = Y. | title = Surgical treatment of a giant cystic tumor of the atrioventricular nodal region. | journal = Interact Cardiovasc Thorac Surg | volume = 8 | issue = 5 | pages = 592-3 | month = May | year = 2009 | doi = 10.1510/icvts.2008.191866 | PMID = 19237400 }}</ref><ref name=pmid16195634>{{Cite journal | last1 = Saito | first1 = S. | last2 = Kobayashi | first2 = J. | last3 = Tagusari | first3 = O. | last4 = Bando | first4 = K. | last5 = Niwaya | first5 = K. | last6 = Nakajima | first6 = H. | last7 = Yamagishi | first7 = M. | last8 = Yagihara | first8 = T. | last9 = Kitamura | first9 = S. | title = Successful excision of a cystic tumor of the atrioventricular nodal region. | journal = Circ J | volume = 69 | issue = 10 | pages = 1293-4 | month = Oct | year = 2005 | doi = | PMID = 16195634 }}</ref> | |||
==Gross== | ==Gross== | ||
*"Bump" in the ''triangle of Koch''. | *"Bump" in the ''triangle of Koch''. | ||
*Usually 1-2 mm. | *Usually 1-2 mm. | ||
*Cystic spaces. | *Cystic spaces - often not apparent at gross. | ||
==Microscopic== | ==Microscopic== | ||