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Difference between revisions of "Polyomavirus nephropathy"
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'''Polyomavirus nephropathy''' is a pathology seen in [[Renal_transplant_pathology|renal transplants]]. | |||
==General== | |||
*This pathology is associated with failure of transplanted kidneys.<ref name=pmid216990>{{cite journal |author=Mackenzie EF, Poulding JM, Harrison PR, Amer B |title=Human polyoma virus (HPV)--a significant pathogen in renal transplantation |journal=Proc Eur Dial Transplant Assoc |volume=15 |issue= |pages=352–60 |year=1978 |pmid=216990 |doi= |url=}}</ref> | |||
*Treatment: reduce immunosuppression.<ref name=Nickeleit>Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539]. Accessed on: 8 November 2010.</ref> | |||
*Implicated in [[urothelial carcinoma]] - esp. in renal transplant recipients.<ref name=pmid18971934>{{Cite journal | last1 = Roberts | first1 = IS. | last2 = Besarani | first2 = D. | last3 = Mason | first3 = P. | last4 = Turner | first4 = G. | last5 = Friend | first5 = PJ. | last6 = Newton | first6 = R. | title = Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation. | journal = Br J Cancer | volume = 99 | issue = 9 | pages = 1383-6 | month = Nov | year = 2008 | doi = 10.1038/sj.bjc.6604711 | PMID = 18971934 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Nickeleit/> | |||
*Ground glass-like nuclear inclusions. | |||
*Nuclear enlargement. | |||
===Images=== | |||
<gallery> | |||
Image:Polyomavirus_nephropathy_-_high_mag.jpg | PN - high mag. (WC) | |||
Image:Polyomavirus_nephropathy_-_very_high_mag.jpg | PN - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://tpis1.upmc.com:81/tpis/GU/G00011a.html Polyomavirus (upmc.com)].<ref>URL: [http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html]. Accessed on: 11 November 2011.</ref> | |||
*[http://path.upmc.edu/cases/case582.html Polyomavirus nephropathy - several images (upmc.edu)]. | |||
==IHC== | |||
Features: | |||
*SV40 +ve<ref name=pmid25359127>{{Cite journal | last1 = Lautenschlager | first1 = I. | last2 = Jahnukainen | first2 = T. | last3 = Kardas | first3 = P. | last4 = Lohi | first4 = J. | last5 = Auvinen | first5 = E. | last6 = Mannonen | first6 = L. | last7 = Dumoulin | first7 = A. | last8 = Hirsch | first8 = HH. | last9 = Jalanko | first9 = H. | title = A case of primary JC polyomavirus infection-associated nephropathy. | journal = Am J Transplant | volume = 14 | issue = 12 | pages = 2887-92 | month = Dec | year = 2014 | doi = 10.1111/ajt.12945 | PMID = 25359127 }}</ref> (nuclear staining). | |||
===Images=== | |||
<gallery> | |||
Image:Polyomavirus_nephropathy_-_sv40_-_high_mag.jpg | PN - high mag. (WC/Nephron) | |||
Image:Polyomavirus_nephropathy_-_sv40_-_very_high_mag.jpg | PN - very high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://tpis1.upmc.com:81/tpis/GU/G00011b.html Polyomavirus (upmc.com)]. | |||
==See also== | |||
*[[Renal transplant pathology]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Genitourinary pathology]] | |||