Polyomavirus nephropathy

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Polyomavirus nephropathy is a pathology seen in renal transplants.

General

  • This pathology is associated with failure of transplanted kidneys.[1]
  • Treatment: reduce immunosuppression.[2]
  • Implicated in urothelial carcinoma - esp. in renal transplant recipients.[3]

Microscopic

Features:[2]

  • Ground glass-like nuclear inclusions.
  • Nuclear enlargement.

Images

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IHC

Features:

Images

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See also

References

  1. Mackenzie EF, Poulding JM, Harrison PR, Amer B (1978). "Human polyoma virus (HPV)--a significant pathogen in renal transplantation". Proc Eur Dial Transplant Assoc 15: 352–60. PMID 216990.
  2. 2.0 2.1 Nickeleit, Volker; Singh, Harsharan K. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations. URL: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A74503#A74539. Accessed on: 8 November 2010.
  3. Roberts, IS.; Besarani, D.; Mason, P.; Turner, G.; Friend, PJ.; Newton, R. (Nov 2008). "Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation.". Br J Cancer 99 (9): 1383-6. doi:10.1038/sj.bjc.6604711. PMID 18971934.
  4. URL: http://tpis1.upmc.com:81/tpis/kidney/KAINbk.html. Accessed on: 11 November 2011.
  5. Lautenschlager, I.; Jahnukainen, T.; Kardas, P.; Lohi, J.; Auvinen, E.; Mannonen, L.; Dumoulin, A.; Hirsch, HH. et al. (Dec 2014). "A case of primary JC polyomavirus infection-associated nephropathy.". Am J Transplant 14 (12): 2887-92. doi:10.1111/ajt.12945. PMID 25359127.