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Difference between revisions of "Programmed cell death 1"
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Cytotoxic T cell function is regulated by receptor pairs found on the tumour and lymphocyte:<ref name=pmid22658126>{{Cite journal | last1 = Ribas | first1 = A. | title = Tumor immunotherapy directed at PD-1. | journal = N Engl J Med | volume = 366 | issue = 26 | pages = 2517-9 | month = Jun | year = 2012 | doi = 10.1056/NEJMe1205943 | PMID = 22658126 }}</ref> | Cytotoxic T cell function is regulated by receptor pairs found on the tumour and lymphocyte:<ref name=pmid22658126>{{Cite journal | last1 = Ribas | first1 = A. | title = Tumor immunotherapy directed at PD-1. | journal = N Engl J Med | volume = 366 | issue = 26 | pages = 2517-9 | month = Jun | year = 2012 | doi = 10.1056/NEJMe1205943 | PMID = 22658126 }}</ref> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! | ! Function | ||
! Tumour cell | ! Tumour cell | ||
! T cell | ! T cell | ||
|- | |- | ||
| Antigen | | Antigen presentation | ||
| MHC | | MHC | ||
| TCR | | TCR | ||
|- | |- | ||
| | | Signal inhibition | ||
| [[PD-1]] | | [[PD-1]] | ||
| PD-L1 (CD274), PD-L2 (CD273) | | PD-L1 (CD274), PD-L2 (CD273) | ||