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Difference between revisions of "Programmed cell death 1"
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It is also known as '''CD279'''. | It is also known as '''CD279'''. | ||
PD1 binds with [[programmed death-ligand 1]] (dealt with separately) and ''programmed death-ligand 2''.<ref name=pmid22658126/> | |||
==Background== | |||
Cytotoxic T cell activation is driven by three sets of receptors:<ref name=pmid22658126>{{Cite journal | last1 = Ribas | first1 = A. | title = Tumor immunotherapy directed at PD-1. | journal = N Engl J Med | volume = 366 | issue = 26 | pages = 2517-9 | month = Jun | year = 2012 | doi = 10.1056/NEJMe1205943 | PMID = 22658126 }}</ref> | |||
{| class="wikitable sortable" | |||
! Pairings | |||
! Tumour cell | |||
! T cell | |||
|- | |||
| Antigen presenting | |||
| MHC | |||
| TCR | |||
|- | |||
| Inhibitory signal | |||
| [[PD-1]] | |||
| PD-L1 (CD274), PD-L2 (CD273) | |||
|} | |||
==Drugs== | ==Drugs== | ||