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Difference between revisions of "Acquired cystic disease-associated renal cell carcinoma"
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Acquired cystic disease-associated renal cell carcinoma (view source)
Revision as of 23:37, 26 May 2018
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| Caption = Acquired cystic disease-associated renal cell carcinoma. [[H&E stain]]. | | Caption = Acquired cystic disease-associated renal cell carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = sieve-like architecture (tubular structures/cribriforming), tumour cells with prominent nucleoli and eosinophilic cytoplasm, | | Micro = sieve-like architecture (tubular structures/cribriforming), tumour cells with prominent nucleoli and eosinophilic cytoplasm, oxalate crystals - seen best in [[polarized light]], acquired cystic disease in background, +/-papillary structures - common minor component | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[acquired cystic renal disease]], [[papillary renal cell carcinoma]], [[hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]] | | LMDDx = [[acquired cystic renal disease]], [[papillary renal cell carcinoma]], [[hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]] | ||
| Line 17: | Line 17: | ||
| Staging = [[kidney cancer staging]] | | Staging = [[kidney cancer staging]] | ||
| Site = [[kidney]] - see [[kidney tumours]] | | Site = [[kidney]] - see [[kidney tumours]] | ||
| Assdx = [[end-stage renal disease]] | | Assdx = [[acquired cystic disease of the kidney]], [[end-stage renal disease]] | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = renal mass and cysts | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = nephrectomy | ||
}} | }} | ||
'''Acquired cystic disease-associated renal cell carcinoma''', abbreviated '''ACD-RCC''', is a rare [[kidney cancer]] that arises in the context of [[chronic renal failure]]. | '''Acquired cystic disease-associated renal cell carcinoma''', abbreviated '''ACD-RCC''', is a rare [[kidney cancer]] that arises in the context of [[chronic renal failure]]. | ||
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==General== | ==General== | ||
*Arise in the context of [[acquired cystic disease of the kidney]] which is seen in the context of [[end-stage renal disease]] (ESRD).<ref name=pmid23471757>{{Cite journal | last1 = Ahn | first1 = S. | last2 = Kwon | first2 = GY. | last3 = Cho | first3 = YM. | last4 = Jun | first4 = SY. | last5 = Choi | first5 = C. | last6 = Kim | first6 = HJ. | last7 = Park | first7 = YW. | last8 = Park | first8 = WS. | last9 = Shim | first9 = JW. | title = Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features. | journal = Med Mol Morphol | volume = | issue = | pages = | month = Mar | year = 2013 | doi = 10.1007/s00795-013-0028-x | PMID = 23471757 }}</ref> | *Arise in the context of [[acquired cystic disease of the kidney]] which is seen in the context of [[end-stage renal disease]] (ESRD).<ref name=pmid23471757>{{Cite journal | last1 = Ahn | first1 = S. | last2 = Kwon | first2 = GY. | last3 = Cho | first3 = YM. | last4 = Jun | first4 = SY. | last5 = Choi | first5 = C. | last6 = Kim | first6 = HJ. | last7 = Park | first7 = YW. | last8 = Park | first8 = WS. | last9 = Shim | first9 = JW. | title = Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features. | journal = Med Mol Morphol | volume = | issue = | pages = | month = Mar | year = 2013 | doi = 10.1007/s00795-013-0028-x | PMID = 23471757 }}</ref> | ||
* | *May have aggressive course - including [[lymph node metastases]] and death.<ref name=pmid16434887>{{Cite journal | last1 = Tickoo | first1 = SK. | last2 = dePeralta-Venturina | first2 = MN. | last3 = Harik | first3 = LR. | last4 = Worcester | first4 = HD. | last5 = Salama | first5 = ME. | last6 = Young | first6 = AN. | last7 = Moch | first7 = H. | last8 = Amin | first8 = MB. | title = Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. | journal = Am J Surg Pathol | volume = 30 | issue = 2 | pages = 141-53 | month = Feb | year = 2006 | doi = | PMID = 16434887 }}</ref> | ||
==Gross== | ==Gross== | ||
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**Focal papillary architecture - common.<ref name=pmid16434887>{{Cite journal | last1 = Tickoo | first1 = SK. | last2 = dePeralta-Venturina | first2 = MN. | last3 = Harik | first3 = LR. | last4 = Worcester | first4 = HD. | last5 = Salama | first5 = ME. | last6 = Young | first6 = AN. | last7 = Moch | first7 = H. | last8 = Amin | first8 = MB. | title = Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. | journal = Am J Surg Pathol | volume = 30 | issue = 2 | pages = 141-53 | month = Feb | year = 2006 | doi = | PMID = 16434887 }}</ref> | **Focal papillary architecture - common.<ref name=pmid16434887>{{Cite journal | last1 = Tickoo | first1 = SK. | last2 = dePeralta-Venturina | first2 = MN. | last3 = Harik | first3 = LR. | last4 = Worcester | first4 = HD. | last5 = Salama | first5 = ME. | last6 = Young | first6 = AN. | last7 = Moch | first7 = H. | last8 = Amin | first8 = MB. | title = Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. | journal = Am J Surg Pathol | volume = 30 | issue = 2 | pages = 141-53 | month = Feb | year = 2006 | doi = | PMID = 16434887 }}</ref> | ||
**Tumour cells have prominent nucleoli ([[ISUP nucleolar grade]] 3) and eosinophilic cytoplasm. | **Tumour cells have prominent nucleoli ([[ISUP nucleolar grade]] 3) and eosinophilic cytoplasm. | ||
* | *Oxalate crystals - '''important'''. | ||
**Look somewhat like cholesterol clefts. | **Look somewhat like cholesterol clefts. | ||
**Seen easily in [[polarized light]]. | **Seen easily in [[polarized light]]. | ||
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*[[Renal tumours]]. | *[[Renal tumours]]. | ||
*[[Acquired cystic renal disease]]. | *[[Acquired cystic renal disease]]. | ||
*[[End-stage kidney]]. | |||
==References== | ==References== | ||