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Difference between revisions of "Acquired cystic disease-associated renal cell carcinoma"
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Acquired cystic disease-associated renal cell carcinoma (view source)
Revision as of 03:41, 27 April 2016
, 03:41, 27 April 2016→Microscopic
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *Fused tubular structures/cribriforming/sieve-like architecture.<ref>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }} | ||
</ref> | </ref> | ||
**[[ | **Focal papillary architecture - common.<ref name=pmid16434887>{{Cite journal | last1 = Tickoo | first1 = SK. | last2 = dePeralta-Venturina | first2 = MN. | last3 = Harik | first3 = LR. | last4 = Worcester | first4 = HD. | last5 = Salama | first5 = ME. | last6 = Young | first6 = AN. | last7 = Moch | first7 = H. | last8 = Amin | first8 = MB. | title = Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. | journal = Am J Surg Pathol | volume = 30 | issue = 2 | pages = 141-53 | month = Feb | year = 2006 | doi = | PMID = 16434887 }}</ref> | ||
**Tumour cells have prominent nucleoli ([[ISUP nucleolar grade]] 3) and eosinophilic cytoplasm. | |||
*Oxylate crystals - '''important'''. | *Oxylate crystals - '''important'''. | ||
**Look somewhat like cholesterol clefts. | **Look somewhat like cholesterol clefts. | ||
**Seen easily in [[polarized light]]. | **Seen easily in [[polarized light]]. | ||
*[[Acquired cystic disease]] in background - required. | |||
**Changes of [[end-stage kidney]] (obsolete glomeruli, thyroidization, interstitial fibrosis). | |||
DDx: | DDx: | ||