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Difference between revisions of "Noninvasive follicular thyroid neoplasm with papillary-like nuclear features"
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Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (view source)
Revision as of 17:52, 5 April 2016
, 17:52, 5 April 2016→Microscopic
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==Microscopic== | ==Microscopic== | ||
Features of NIFTP:<ref name=thompson>URL: [http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf]. Accessed on: 5 April 2016.</ref> | Features of NIFTP:<ref name=thompson>URL: [http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf http://lesterthompsonmd.com/pdf/2016%20SCPMG%20Thyroid%20NIFTP%20Education%20Module.pdf]. Accessed on: 5 April 2016.</ref> | ||
*Major features: | *Major features - all required for diagnosis: | ||
**Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following: | **Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following: | ||
**#Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions). | **#Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions). | ||
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**Follicular pattern. | **Follicular pattern. | ||
*Minor features: | *Minor features: | ||
**Intratumoural fibrosis, eosinophilic and paucicellular. | **Intratumoural fibrosis, eosinophilic and paucicellular. | ||
**Clefting of follicules from surrounding stroma. | **Clefting of follicules from surrounding stroma. | ||
**Multinucleated cells. | **Multinucleated cells. | ||
**Dark colloid. | |||
Features that exclude the diagnosis of NIFTP:<ref name=thompson/> | Features that exclude the diagnosis of NIFTP:<ref name=thompson/> | ||
*True papillae >1% | *True papillae >1% within the tumour. | ||
*[[Psammoma bodies]]. | *[[Psammoma bodies]]. | ||
*Infiltration of the capsule ''or'' an infiltrative border. | *Infiltration of the capsule ''or'' an infiltrative border. | ||