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Neuromuscular pathology (view source)
Revision as of 14:55, 8 December 2015
, 14:55, 8 December 2015→Approach
Jensflorian (talk | contribs) (→Fibre types: Morphology, ATPase) |
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===Approach=== | ===Approach=== | ||
General: | General: | ||
#Size variation - in groups (neurogenic) vs. singular (myogenic). | *Neurogenic or myopathic? | ||
*Acute or chronic? | |||
Check: | |||
#Size variation - in groups (neurogenic, Dystrophinopathies) vs. singular scattered (myogenic, acute neurogenic). | |||
#Shape - angulated (neurogenic) vs. round (myogenic). | #Shape - angulated (neurogenic) vs. round (myogenic). | ||
#Position of nuclei - peripheral (normal); central (myogenic; centronuclear myopathy<ref>URL: [http://www.igbmc.fr/recherche/Dep_NG/Eq_JLaporte/JL3.html http://www.igbmc.fr/recherche/Dep_NG/Eq_JLaporte/JL3.html]. Accessed on: 26 October 2010.</ref>). | #Position of nuclei - peripheral (normal); central (myogenic; centronuclear myopathy<ref>URL: [http://www.igbmc.fr/recherche/Dep_NG/Eq_JLaporte/JL3.html http://www.igbmc.fr/recherche/Dep_NG/Eq_JLaporte/JL3.html]. Accessed on: 26 October 2010.</ref>). | ||
#[[Necrosis]] - suggests myogenic. | #[[Necrosis]] & regeneration - suggests acute myogenic. | ||
#Fibrosis - suggests myogenic. | #Fibrosis - suggests chronic myogenic. | ||
#Inflammation - suggest myogenic vs. systemic inflammatory. | #Inflammation - suggest myogenic vs. systemic inflammatory. | ||
#*Lymphocytes, macrophages, eosinophils - or even neoplastic? | |||
#Fibre type predominance - suggest congenital myopathy (esp. in small type 1 fibres), demyelinating neuropathy. | |||
Other: | Other: | ||
#Obvious abnormality vs. minimal change. | #Obvious abnormality vs. minimal change. | ||
#Diffuse vs. focal change. | #Diffuse vs. focal change. | ||
#Pathology in adjacent vessels or connective tissue. | |||
==Processing of muscle biopsies== | ==Processing of muscle biopsies== | ||