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Granulomatous appendicitis (view source)
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'''Granulomatous appendicitis''' is an inflammatory process involving the [[vermiform appendix]] characterized by [[granulomas]]. | |||
==General== | |||
Most common cause: | |||
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref> | |||
DDx:<ref>[http://granuloma.homestead.com/appendicitis.html http://granuloma.homestead.com/appendicitis.html]</ref> | |||
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref> | |||
**Yersinia = gram negative rod (red on [[Gram stain]]). | |||
**"Safety pin"-like appearance<ref>URL: [http://www.cdc.gov/ncidod/dvbid/plague/p1.htm http://www.cdc.gov/ncidod/dvbid/plague/p1.htm]. Accessed on: 30 June 2011.</ref> - approximately 0.5 micrometers diameter x 2 micrometers length. | |||
*Other micro-organism ([[TB]], fungus). | |||
*[[Crohn's disease]]. | |||
*[[Sarcoidosis]]. | |||
*Foreign body reaction. | |||
*Interval (delayed) appendectomy. | |||
**Approximately 60% of delayed appendectomies have granulomas.<ref name=pmid12883248>{{Cite journal | last1 = Guo | first1 = G. | last2 = Greenson | first2 = JK. | title = Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis. | journal = Am J Surg Pathol | volume = 27 | issue = 8 | pages = 1147-51 | month = Aug | year = 2003 | doi = | PMID = 12883248 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*[[Granulomas]]. | |||
*+/-"Safety pin"-like organisms (Yersinia). | |||
Image(s): | |||
<gallery> | |||
Image:Appendix Appendicitis Acute Granulomatous 2 PA.JPG|Granulomatous Appendicitis (SKB) | |||
Image:Appendix Appendicitis Acute Granulomatous PA.JPG|Suppurating Granulomatous Appendicitis (SKB) | |||
Image:Appendix Appendicitis GranulomatousSuppurating Yersinia-LP PA.JPG|Suppurating Granulomatous Yersinia Appendicitis (SKB) | |||
Image:Appendix Appendicitis GranulomatousSuppurating Yersinia-HP PA.JPG|Suppurating Granulomatous Yersinia Appendicitis Yersinia(SKB) | |||
</gallery> | |||
*[http://www.cdc.gov/ncidod/dvbid/plague/p1.htm Yersinia (CDC)]. | |||
==See also== | |||
*[[Vermiform appendix]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Vermiform appendix]] | |||