Granulomatous appendicitis

From Libre Pathology
Jump to: navigation, search

Granulomatous appendicitis is an inflammatory process involving the vermiform appendix characterized by granulomas.

Interval appendectomy redirects to this article, as granulomas are often seen in that context.

General

Most common cause:

  • Yersinia appendicitis.[1]

DDx:[2]

  • Yersinia appendicitis.[1]
    • Yersinia = gram negative rod (red on Gram stain).
    • "Safety pin"-like appearance[3] - approximately 0.5 micrometers diameter x 2 micrometers length.
  • Other micro-organism (TB, fungus).
  • Crohn's disease.
  • Sarcoidosis.
  • Foreign body reaction.
  • Interval (delayed) appendectomy.
    • Approximately 60% of delayed appendectomies have granulomas.[4]

Microscopic

Features:

  • Granulomas.
  • +/-"Safety pin"-like organisms (Yersinia).

Image(s):

See also

References

  1. 1.0 1.1 Lamps LW, Madhusudhan KT, Greenson JK, et al. (April 2001). "The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study". Am. J. Surg. Pathol. 25 (4): 508–15. PMID 11257626.
  2. http://granuloma.homestead.com/appendicitis.html
  3. URL: http://www.cdc.gov/ncidod/dvbid/plague/p1.htm. Accessed on: 30 June 2011.
  4. Guo, G.; Greenson, JK. (Aug 2003). "Histopathology of interval (delayed) appendectomy specimens: strong association with granulomatous and xanthogranulomatous appendicitis.". Am J Surg Pathol 27 (8): 1147-51. PMID 12883248.