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Difference between revisions of "Angiocentric glioma"
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Angiocentric glioma (view source)
Revision as of 10:52, 23 September 2015
, 10:52, 23 September 2015wikify
Jensflorian (talk | contribs) (more images added) |
Jensflorian (talk | contribs) m (wikify) |
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| LMDDx = [[astrocytoma]], [[ependymoma]]. | | LMDDx = [[astrocytoma]], [[ependymoma]]. | ||
| Stains = | | Stains = | ||
| IHC = GFAP +/-ve, EMA +/-ve. | | IHC = GFAP +/-ve, [[EMA]] +/-ve. | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 53: | Line 53: | ||
*Low cellularity and rich myxoid background- when compared to classical astrocytomas. | *Low cellularity and rich myxoid background- when compared to classical astrocytomas. | ||
**Mitotic activity may lead to eroneous diagnosis of [[anaplastic astrocytoma]]. | **Mitotic activity may lead to eroneous diagnosis of [[anaplastic astrocytoma]]. | ||
*Variably GFAP, EMA and S-100 positive | *Variably GFAP, [[EMA]] and S-100 positive | ||
* No IDH1/2 mutations. <ref>{{Cite journal | last1 = Raghunathan | first1 = A. | last2 = Olar | first2 = A. | last3 = Vogel | first3 = H. | last4 = Parker | first4 = JR. | last5 = Coventry | first5 = SC. | last6 = Debski | first6 = R. | last7 = Albarracin | first7 = CT. | last8 = Aldape | first8 = KD. | last9 = Cahill | first9 = DP. | title = Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma. | journal = Ann Diagn Pathol | volume = 16 | issue = 4 | pages = 255-9 | month = Aug | year = 2012 | doi = 10.1016/j.anndiagpath.2011.11.003 | PMID = 22445362 }}</ref> | * No IDH1/2 mutations. <ref>{{Cite journal | last1 = Raghunathan | first1 = A. | last2 = Olar | first2 = A. | last3 = Vogel | first3 = H. | last4 = Parker | first4 = JR. | last5 = Coventry | first5 = SC. | last6 = Debski | first6 = R. | last7 = Albarracin | first7 = CT. | last8 = Aldape | first8 = KD. | last9 = Cahill | first9 = DP. | title = Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma. | journal = Ann Diagn Pathol | volume = 16 | issue = 4 | pages = 255-9 | month = Aug | year = 2012 | doi = 10.1016/j.anndiagpath.2011.11.003 | PMID = 22445362 }}</ref> | ||
*MIB-1 between 1-5% | *MIB-1 between 1-5% | ||
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Image:Neuropathology_case_V_03.jpg | Angiocentric glioma - high mag. (WC/jensflorian) | Image:Neuropathology_case_V_03.jpg | Angiocentric glioma - high mag. (WC/jensflorian) | ||
Image:Neuropathology_case_V_04.jpg | Angiocentric glioma - GFAP immunostain (WC/jensflorian) | Image:Neuropathology_case_V_04.jpg | Angiocentric glioma - GFAP immunostain (WC/jensflorian) | ||
Image:Neuropathology_case_V_05.jpg | Angiocentric glioma - EMA immunostain (WC/jensflorian) | Image:Neuropathology_case_V_05.jpg | Angiocentric glioma - [[EMA]] immunostain (WC/jensflorian) | ||
Image:Neuropathology_case_V_06.jpg | Angiocentric glioma - MAP2 immunostain (WC/jensflorian) | Image:Neuropathology_case_V_06.jpg | Angiocentric glioma - MAP2 immunostain (WC/jensflorian) | ||
Image:Neuropathology_case_V_07.jpg | Angiocentric glioma - MIB-1 immunostain (WC/jensflorian) | Image:Neuropathology_case_V_07.jpg | Angiocentric glioma - MIB-1 immunostain (WC/jensflorian) | ||