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Difference between revisions of "Immunohistochemical staining"
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Immunohistochemical staining (view source)
Revision as of 08:08, 23 September 2015
, 08:08, 23 September 2015wikify INI1 p63 STAT6
Jensflorian (talk | contribs) m (→Neuropathology: wikify CD56) |
Jensflorian (talk | contribs) (wikify INI1 p63 STAT6) |
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*PSAP - prostatic-specific acid phosphatase. | *PSAP - prostatic-specific acid phosphatase. | ||
**May be positive in hindgut [[neuroendocrine tumour]]s.<ref name=pmid>{{Cite journal | last1 = Azumi | first1 = N. | last2 = Traweek | first2 = ST. | last3 = Battifora | first3 = H. | title = Prostatic acid phosphatase in carcinoid tumors. Immunohistochemical and immunoblot studies. | journal = Am J Surg Pathol | volume = 15 | issue = 8 | pages = 785-90 | month = Aug | year = 1991 | doi = | PMID = 1712549 }}</ref> | **May be positive in hindgut [[neuroendocrine tumour]]s.<ref name=pmid>{{Cite journal | last1 = Azumi | first1 = N. | last2 = Traweek | first2 = ST. | last3 = Battifora | first3 = H. | title = Prostatic acid phosphatase in carcinoid tumors. Immunohistochemical and immunoblot studies. | journal = Am J Surg Pathol | volume = 15 | issue = 8 | pages = 785-90 | month = Aug | year = 1991 | doi = | PMID = 1712549 }}</ref> | ||
*p63 - stains nuclei of basal cell in normal [[prostate]]. | *[[p63]] - stains nuclei of basal cell in normal [[prostate]]. | ||
*34betaE12 - stains basal cells in normal prostate. | *34betaE12 - stains basal cells in normal prostate. | ||
*AMACR (racemase, P504S<ref>[http://www.antibodies-online.com/antibody/125649/P504S+alphaMethylacylCoA+Racemace+AMACR+Human/ http://www.antibodies-online.com/antibody/125649/P504S+alphaMethylacylCoA+Racemace+AMACR+Human/]</ref>) - present in adenocarcinoma (NOT in normal prostate). | *AMACR (racemase, P504S<ref>[http://www.antibodies-online.com/antibody/125649/P504S+alphaMethylacylCoA+Racemace+AMACR+Human/ http://www.antibodies-online.com/antibody/125649/P504S+alphaMethylacylCoA+Racemace+AMACR+Human/]</ref>) - present in adenocarcinoma (NOT in normal prostate). | ||
*AR - usually present in prostate confined cancers.<ref name=pmid20878946>{{Cite journal | last1 = Fleischmann | first1 = A. | last2 = Rocha | first2 = C. | last3 = Schobinger | first3 = S. | last4 = Seiler | first4 = R. | last5 = Wiese | first5 = B. | last6 = Thalmann | first6 = GN. | title = Androgen receptors are differentially expressed in Gleason patterns of prostate cancer and down-regulated in matched lymph node metastases. | journal = Prostate | volume = 71 | issue = 5 | pages = 453-60 | month = Apr | year = 2011 | doi = 10.1002/pros.21259 | PMID = 20878946 }}</ref> | *AR - usually present in prostate confined cancers.<ref name=pmid20878946>{{Cite journal | last1 = Fleischmann | first1 = A. | last2 = Rocha | first2 = C. | last3 = Schobinger | first3 = S. | last4 = Seiler | first4 = R. | last5 = Wiese | first5 = B. | last6 = Thalmann | first6 = GN. | title = Androgen receptors are differentially expressed in Gleason patterns of prostate cancer and down-regulated in matched lymph node metastases. | journal = Prostate | volume = 71 | issue = 5 | pages = 453-60 | month = Apr | year = 2011 | doi = 10.1002/pros.21259 | PMID = 20878946 }}</ref> | ||
*CAP cocktail - [[AKA]] ''CAP'', [[AKA]] ''PIN-4'', [[AKA]] ''PIN''. | *CAP cocktail - [[AKA]] ''CAP'', [[AKA]] ''PIN-4'', [[AKA]] ''PIN''. | ||
**Consists of: AMACR, p63 and HMWK. | **Consists of: AMACR, [[p63]] and HMWK. | ||
**Image: [http://www.webpathology.com/image.asp?case=96&n=5 CAP cocktail (webpathology.com)]. | **Image: [http://www.webpathology.com/image.asp?case=96&n=5 CAP cocktail (webpathology.com)]. | ||
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====Serous markers==== | ====Serous markers==== | ||
*WT-1, CA-125, D2-40. | *[[WT-1]], CA-125, D2-40. | ||
===[[Liver neoplasms|Liver]]=== | ===[[Liver neoplasms|Liver]]=== | ||
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*[[EMA]] +ve: [[meningioma]], [[ependymoma]] (cytoplasm dot-like).<ref name=Ref_PSNP12>{{Ref PSNP|12}}</ref> | *[[EMA]] +ve: [[meningioma]], [[ependymoma]] (cytoplasm dot-like).<ref name=Ref_PSNP12>{{Ref PSNP|12}}</ref> | ||
*[[ATRX]] -ve: [[astrocytoma]] | *[[ATRX]] -ve: [[astrocytoma]] | ||
*[[INI1]] -ve: [[AT/RT]] | |||
Tumour (low-grade gliomas): | Tumour (low-grade gliomas): | ||
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*Caldesmon - muscle. | *Caldesmon - muscle. | ||
*PDGFR - GIST. | *PDGFR - GIST. | ||
*[[STAT6]] - [[Hemangiopericytoma]]/SFT. | |||
==Muscle markers== | ==Muscle markers== | ||