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[[Image:Serous carcinoma - omentum -- very high mag.jpg|200px|thumb|Psammoma bodies in [[serous carcinoma]]. [[H&E stain]].]] | [[Image:Serous carcinoma - omentum -- very high mag.jpg|200px|thumb|Psammoma bodies in [[serous carcinoma]]. [[H&E stain]].]] | ||
[[Image:Meningioma showing Psammoma body.jpg|200px|thumb|Psammoma bodies in [[meningioma]]. [[H&E stain]].]] | |||
'''Psammoma bodies''' appear in benign and malignant conditions. Their presence can help focus the DDx.<ref>{{Cite journal | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 | URL = http://onlinelibrary.wiley.com/doi/10.1002/cncr.20161/full}}</ref> | '''Psammoma bodies''' appear in benign and malignant conditions. Their presence can help focus the DDx.<ref>{{Cite journal | last1 = Parwani | first1 = AV. | last2 = Chan | first2 = TY. | last3 = Ali | first3 = SZ. | title = Significance of psammoma bodies in serous cavity fluid: a cytopathologic analysis. | journal = Cancer | volume = 102 | issue = 2 | pages = 87-91 | month = Apr | year = 2004 | doi = 10.1002/cncr.20161 | PMID = 15098252 | URL = http://onlinelibrary.wiley.com/doi/10.1002/cncr.20161/full}}</ref> | ||
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*Intrauterine device (IUD).<ref name=pmid12278909>{{Cite journal | last1 = Boon | first1 = ME. | last2 = Kirk | first2 = RS. | last3 = De Graaff Guilloud | first3 = JC. | title = Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. | journal = Contracept Deliv Syst | volume = 2 | issue = 3 | pages = 231-6 | month = Jul | year = 1981 | doi = | PMID = 12278909 }}</ref> | *Intrauterine device (IUD).<ref name=pmid12278909>{{Cite journal | last1 = Boon | first1 = ME. | last2 = Kirk | first2 = RS. | last3 = De Graaff Guilloud | first3 = JC. | title = Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. | journal = Contracept Deliv Syst | volume = 2 | issue = 3 | pages = 231-6 | month = Jul | year = 1981 | doi = | PMID = 12278909 }}</ref> | ||
*[[Endometrial polyp]].<ref name=pmid11854631>{{cite journal |author=Fausett MB, Zahn CM, Kendall BS, Barth WH |title=The significance of psammoma bodies that are found incidentally during endometrial biopsy |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=2 |pages=180–3 |year=2002 |month=February |pmid=11854631 |doi= |url=}}</ref> | *[[Endometrial polyp]].<ref name=pmid11854631>{{cite journal |author=Fausett MB, Zahn CM, Kendall BS, Barth WH |title=The significance of psammoma bodies that are found incidentally during endometrial biopsy |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=2 |pages=180–3 |year=2002 |month=February |pmid=11854631 |doi= |url=}}</ref> | ||
*[[Meningioma]]. <ref>{{Cite journal | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue = | pages = 255-62 | month = Apr | year = 1961 | doi = | PMID = 13752577 }}</ref> | |||
*[[Pituitary adenoma]]. <ref>{{Cite journal | last1 = Wolfson | first1 = WL. | last2 = Rosenthal | first2 = DL. | last3 = Harney | first3 = B. | title = Psammoma bodies in pituitary adenoma. | journal = Acta Cytol | volume = 23 | issue = 1 | pages = 90-2 | month = | year = | doi = | PMID = 285558 }}</ref> | |||
===Malignant=== | ===Malignant=== | ||
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*[[Somatostatinoma]], [[duodenum|duodenal]].<ref name=pmid21437171>{{Cite journal | last1 = Kim | first1 = JA. | last2 = Choi | first2 = WH. | last3 = Kim | first3 = CN. | last4 = Moon | first4 = YS. | last5 = Chang | first5 = SH. | last6 = Lee | first6 = HR. | title = Duodenal somatostatinoma: a case report and review. | journal = Korean J Intern Med | volume = 26 | issue = 1 | pages = 103-7 | month = Mar | year = 2011 | doi = 10.3904/kjim.2011.26.1.103 | PMID = 21437171 }}</ref> | *[[Somatostatinoma]], [[duodenum|duodenal]].<ref name=pmid21437171>{{Cite journal | last1 = Kim | first1 = JA. | last2 = Choi | first2 = WH. | last3 = Kim | first3 = CN. | last4 = Moon | first4 = YS. | last5 = Chang | first5 = SH. | last6 = Lee | first6 = HR. | title = Duodenal somatostatinoma: a case report and review. | journal = Korean J Intern Med | volume = 26 | issue = 1 | pages = 103-7 | month = Mar | year = 2011 | doi = 10.3904/kjim.2011.26.1.103 | PMID = 21437171 }}</ref> | ||
*[[Papillary renal cell carcinoma]]. | *[[Papillary renal cell carcinoma]]. | ||
*[[Meningioma]]. | *Anaplastic [[Meningioma]].<ref>{{Cite journal | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue = | pages = 255-62 | month = Apr | year = 1961 | doi = | PMID = 13752577 }}</ref> | ||
*[[Mesothelioma]]. | *[[Mesothelioma]]. | ||
Memory device ''PSaMMoma'': '''P'''apillary (thyroid, renal), '''S'''erous (ovary), '''M'''eningioma, '''M'''esothelioma.<ref>URL: [http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html]. Accessed on: 15 January 2012.</ref> | Memory device ''PSaMMoma'': '''P'''apillary (thyroid, renal), '''S'''erous (ovary), '''M'''eningioma, '''M'''esothelioma.<ref>URL: [http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html http://ome.umaryland.edu/AcademicD/practiceExams/path/path_findings.html]. Accessed on: 15 January 2012.</ref> | ||
Isolated psammoma bodies in smears or aspirates are an unreliable predictor of papillary carcinoma. <ref>{{Cite journal | last1 = Ellison | first1 = E. | last2 = Lapuerta | first2 = P. | last3 = Martin | first3 = SE. | title = Psammoma bodies in fine-needle aspirates of the thyroid: predictive value for papillary carcinoma. | journal = Cancer | volume = 84 | issue = 3 | pages = 169-75 | month = Jun | year = 1998 | doi = | PMID = 9678732 }}</ref> | |||
==See also== | ==See also== | ||