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Difference between revisions of "Medullary thyroid carcinoma"
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Medullary thyroid carcinoma (view source)
Revision as of 03:42, 23 March 2015
, 03:42, 23 March 2015→Microscopic
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==Microscopic== | ==Microscopic== | ||
Architecture - various | |||
*Nested with delicate vascular septa | |||
*Trabecular | |||
*Tubular/glandular | |||
*Pseudo-papillary | |||
Cells | |||
*Polygonal to spindle to small cells | |||
*Amphophilic, somewhat granular cytoplasm | |||
*Cells may have a more bizarre appearance | |||
*Good clue is the interstitial oedema, giving the appearance that the cells are 'falling apart' | |||
Stroma | |||
*+/-[[Amyloid]] deposits - fluffy appearing acellular eosinophilic material in the cytoplasm. | |||
*Stroma is vascular and can show haemorrhage, hyalinised collagen, oedema or metaplastic bone | |||
*Coarse calcification | |||
*True psammoma bodies may be present | |||
Nuclei | |||
*Nuclei with "neuroendocrine features". | *Nuclei with "neuroendocrine features". | ||
**Small, round nuclei. | **Small, round nuclei. | ||
**Coarse chromatin (''salt and pepper nuclei''). | **Coarse chromatin (''salt and pepper nuclei''). | ||
*+/-[[C-cell hyperplasia]] - seen with familial forms of MTC. | *+/-[[C-cell hyperplasia]] - seen with familial forms of MTC. | ||
**C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale. | **C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale. | ||