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Difference between revisions of "Sertoli-Leydig cell tumour"
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→Microscopic
| Line 22: | Line 22: | ||
*Well differentiated - | *Well differentiated - | ||
**Mature Sertoli cells | **Mature Sertoli cells form tubules | ||
**Stroma is fibrous and contains clusters of Leydig | |||
cells | cells | ||
*Intermediate to poorly differentiated - | *Intermediate to poorly differentiated - | ||
**A more disorganized, more cellular tumor | **A more disorganized, more cellular, 'bluer' tumor | ||
**Less mature Sertoli cells growing in trabeculae and nests with some tubule formation, either round or retiform. | |||
**Leydig cells, either singly or in clusters, are present in an immature, cellular stroma. | |||
DDx: | DDx: | ||
*[[Endometrioid carcinoma of the ovary]]. | *[[Endometrioid carcinoma of the ovary]] (sertoliform variant) - should be positive for EMA, negative for inhibin and calretinin. | ||
*Luteinized [[adult granulosa cell tumour]] - super rare, 50% of cell with eosinophilic cytoplasm, other findings of granulosa cell tumour, e.g. Call-Exner bodies.<ref name=pmid21804396>{{Cite journal | last1 = Ganesan | first1 = R. | last2 = Hirschowitz | first2 = L. | last3 = Baltrušaitytė | first3 = I. | last4 = McCluggage | first4 = WG. | title = Luteinized adult granulosa cell tumor--a series of 9 cases: revisiting a rare variant of adult granulosa cell tumor. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 452-9 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214b17f | PMID = 21804396 }}</ref> | *Luteinized [[adult granulosa cell tumour]] - super rare, 50% of cell with eosinophilic cytoplasm, other findings of granulosa cell tumour, e.g. Call-Exner bodies.<ref name=pmid21804396>{{Cite journal | last1 = Ganesan | first1 = R. | last2 = Hirschowitz | first2 = L. | last3 = Baltrušaitytė | first3 = I. | last4 = McCluggage | first4 = WG. | title = Luteinized adult granulosa cell tumor--a series of 9 cases: revisiting a rare variant of adult granulosa cell tumor. | journal = Int J Gynecol Pathol | volume = 30 | issue = 5 | pages = 452-9 | month = Sep | year = 2011 | doi = 10.1097/PGP.0b013e318214b17f | PMID = 21804396 }}</ref> | ||