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Difference between revisions of "Sertoli-Leydig cell tumour"
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→Microscopic
(→IHC) |
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# Sertoli ''or'' Leydig cells.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | # Sertoli ''or'' Leydig cells.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | ||
#* Leydig cells: | #* Leydig cells: | ||
#** Abundant solid eosinophilic cytoplasm. | #**Polygonal pink cells | ||
#** Abundant solid or somewhat granular eosinophilic cytoplasm. | |||
#** Round nuclei with fine chromatin and a small or indistinct [[nucleolus]]. | #** Round nuclei with fine chromatin and a small or indistinct [[nucleolus]]. | ||
#** Often in small clusters ~ 5-25 cells/cluster. | #** Often in small clusters ~ 5-25 cells/cluster. | ||
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# Stroma. | # Stroma. | ||
# +/- Sarcomatous features (mucinous glands, bone, cartilage). | # +/- Sarcomatous features (mucinous glands, bone, cartilage). | ||
*Well differentiated - | |||
**Mature Sertoli cells line form tubules that grow in a fibrous stroma containing clusters of Leydig | |||
cells | |||
*Intermediate to poorly differentiated - | |||
**A more disorganized, more cellular tumor with less mature Sertoli cells growing in trabeculae and nests. Some tubule formation, either round or retiform. Leydig cells, either singly or in clusters, are present in a cellular stroma. | |||
DDx: | DDx: | ||